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Article
Open AccessGenome-Wide Association Study (GWAS) of dental caries in diverse populations
Dental caries is one of the most common chronic diseases and is influenced by a complex interplay of genetic and environmental factors. Most previous genetic studies of caries have focused on identifying genes...
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Article
Open AccessWhole genome sequencing of orofacial cleft trios from the Gabriella Miller Kids First Pediatric Research Consortium identifies a new locus on chromosome 21
Orofacial clefts (OFCs) are among the most prevalent craniofacial birth defects worldwide and create a significant public health burden. The majority of OFCs are non-syndromic, and the genetic etiology of non-...
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Article
Open AccessNovel caries loci in children and adults implicated by genome-wide analysis of families
Dental caries is a common chronic disease among children and adults alike, posing a substantial health burden. Caries is affected by multiple genetic and environmental factors, and prior studies have found tha...
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Article
Open AccessMega2: validated data-reformatting for linkage and association analyses
In a typical study of the genetics of a complex human disease, many different analysis programs are used, to test for linkage and association. This requires extensive and careful data reformatting, as many of ...
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Article
Open AccessTwo-dimensional linkage analyses of rheumatoid arthritis
Rheumatoid arthritis (RA) is a multifactorial disease with complex genetic etiology, about which little is known. Here, we apply a two-stage procedure in which a quick first-stage analysis was used to narrow d...
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Article
Open AccessAnalysis of alcohol dependence phenotype in the COGA families using covariates to detect linkage
Linkage analysis methods that incorporate etiological heterogeneity of complex diseases are likely to demonstrate greater power than traditional linkage analysis methods. Several such methods use covariates to...
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Article
Open AccessLinkage analysis of adult height with parent-of-origin effects in the Framingham Heart Study
Current linkage analysis methods for quantitative traits do not usually incorporate imprinting effects. Here, we carried out genome-wide linkage analysis for loci influencing adult height in the Framingham Hea...