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    Article

    Asymmetric Contribution of Blastomere Lineages of First Division of the Zygote to Entire Human Body Using Post-Zygotic Variants

    In humans, after fertilization, the zygote divides into two 2n diploid daughter blastomeres. During this division, DNA is replicated, and the remaining mutually exclusive genetic mutations in the genome of eac...

    Seong Gyu Kwon, Geon Hue Bae, June Hyug Choi… in Tissue Engineering and Regenerative Medici… (2022)

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    Article

    Restoration of Immune Privilege in Human Dermal Papillae Controlling Epithelial-Mesenchymal Interactions in Hair Formation

    Hair follicles are among a handful of organs that exhibit immune privilege. Dysfunction of the hair follicle immune system underlies the development of inflammatory diseases, such as alopecia areata.

    Jung Min Park, Mee Sook Jun, Jung-A. Kim… in Tissue Engineering and Regenerative Medici… (2022)

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    Clonal dynamics in early human embryogenesis inferred from somatic mutation

    Cellular dynamics and fate decision in early human embryogenesis remain largely unknown owing to the challenges of performing studies in human embryos1. Here, we explored whole-genomes of 334 single-cell colonies...

    Seongyeol Park, Nanda Maya Mali, Ryul Kim, Jeong-Woo Choi, Junehawk Lee… in Nature (2021)