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Chapter
Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock
Three recombinant octameric mutants of human normal adult hemoglobin (Hb A), rHb (αN78C), rHb (αN78C/L29F), and rHb (αN78C/L29W), were expressed in our Eschericia coli expression system and purified. They were us...
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Article
Backbone Resonance Assignment of Human Adult Hemoglobin in the Eeoxy Form
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Article
Side-chain assignments of methyl-containing residues in a uniformly 13C-labeled hemoglobin in the carbonmonoxy form
Sequence-specific assignment of the methyl groups in large proteins can be obtained from an MQ-(H)CC m H m -TOCSY experiment on uniformly 13C-la...
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Article
A test of the role of the proximal histidines in the Perutz model for cooperativity in haemoglobin
Human haemoglobin has long been a paradigm for cooperative ligand binding and allostery. Through analysis of the crystal structures of deoxyhaemoglobin and liganded haemoglobin, Perutz proposed a model for coo...