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Article
Open AccessFire-Retarding Asphalt Pavement for Urban Road Tunnels: A State-of-the-Art Review and Beyond
With the rapid urbanization and development of metropolises, urban road tunnels have been constructed at an increasing rate, significantly alleviating urban traffic pressure, and improving urban resilience. Fi...
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Article
Criticality of the third-party partnership in the UTAUT2 framework: an empirical examination of restaurant self-service technology applications
This study aims to examine the critical role of the third-party partnership and extend the Extended Unified Theory of Acceptance and Use of Technology (UTAUT2) framework for restaurant customers’ adoption of s...
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Article
Open AccessEpigenetic regulation of beta-endorphin synthesis in hypothalamic arcuate nucleus neurons modulates neuropathic pain in a rodent pain model
Although beta-endorphinergic neurons in the hypothalamic arcuate nucleus (ARC) synthesize beta-endorphin (β-EP) to alleviate nociceptive behaviors, the underlying regulatory mechanisms remain unknown. Here, we...
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Article
Open AccessEvaluating the role of the nuclear microenvironment in gene function by population-based modeling
The nuclear folding of chromosomes relative to nuclear bodies is an integral part of gene function. Here, we demonstrate that population-based modeling—from ensemble Hi-C data—provides a detailed description o...
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Article
Open AccessCo-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice
Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an upregulation of BCL-2 family anti-apoptotic proteins, incl...
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Article
Open AccessBCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers
KRAS mutations are the most common oncogenic drivers. Sotorasib (AMG510), a covalent inhibitor of KRASG12C, was recently approved for the treatment of KRASG12C-mutated non-small cell lung cancer (NSCLC). However,...
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Chapter and Conference Paper
Protoformer: Embedding Prototypes for Transformers
Transformers have been widely applied in text classification. Unfortunately, real-world data contain anomalies and noisy labels that cause challenges for state-of-art Transformers. This paper proposes Protofor...
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Article
Open AccessDevelopment of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity,
PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because many determinants of PROTAC specificity and activ...
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Chapter and Conference Paper
Experimental Study on Flow Boiling Heat Transfer of Refrigerant R1233zd in Microchannels
The paper reports preliminary measurement results for flow boiling heat transfer of refrigerant R1233zd in parallel horizontal microchannels. The aluminum test section consists of two blocks and has 10 paralle...
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Chapter and Conference Paper
Heat Transfer Measurements for Condensation of FC72 in Microchannels
The paper reports heat transfer measurements for condensation of FC72 in ten parallel horizontal microchannels (1.5 mm deep × 1.0 mm wide) in an aluminum test section.
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Chapter and Conference Paper
Numerical Simulation of Thermal–Hydraulic Performance of a Round Tube-Fin Condenser with Liquid–Vapour Separation
A lumped-parameter model of round tube-fin condensers with (RTFCs-LS) and without (RTFCs) liquid–vapour separation was proposed by Hua et al. [1]. This model appears accurate, simplified and low computational ...
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Article
Quantifying Uncertainties in the Temperature–Time Evolution of Railway Tunnel Fires
Extreme fire events in tunnels can have catastrophic consequences, including loss of lives, structural damage, and major socioeconomic impacts. The fire scenario itself is one of the primary parameters that wo...
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Article
Can error management culture increase work engagement in hotels? The moderating role of gender
This study examines (1) the influence of error management culture on employees’ work engagement; (2) how gender affects the proposed relationship; and (3) the mediating effect of work engagement between error ...
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Article
Producing genome structure populations with the dynamic and automated PGS software
PGS addresses the challenge of reconstructing 3D genomes from cells by applying population-based genome structure modeling. The software models the variability of 3D genome structures across cells, accommodati...
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Article
Inter-domain optical path provisioning with blocking avoidance by intra-domain immediate reroute-based semi-proactive hierarchical PCE
Optical fiber networks have become the foundations of communication system to provide enormous transmission capacity with less cost. Connection blocking is an inherent attribute and influences optical networks...
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Article
Open AccessWidespread of horizontal gene transfer in the human genome
A fundamental concept in biology is that heritable material is passed from parents to offspring, a process called vertical gene transfer. An alternative mechanism of gene acquisition is through horizontal gene...
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Article
CapEx advantages of multi-core fiber networks
We investigate capital expenditure (CapEx) advantages of multi-core fiber (MCF) networks by modeling and solving CapEx-minimized planning problem. Integer linear programming model is established, and numerical...
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Article
Genotoxicity Test of Self-Renovated Ceramics in Primary Human Peripheral Lymphocytes
Zirconia-based ceramics is widely used in dentistry. Different compositions of ceramics have different features. Our self-renovated ceramics become more machinable without scarifying its dental restoration pro...
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Article
Biodegradable Effect of PLGA Membrane in Alveolar Bone Regeneration on Beagle Dog
Guided bone regeneration (GBR) is a principle adopted from guided tissue regeneration (GTR). Wherein, GBR is used for the healing of peri-implant bony dehiscences, for the immediate placement of implants into ...
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Article
Experimenting with bandwidth-variable routing and signaling on a large-scale ASON test-bed
Bandwidth-variable (BV) optical networks have been proposed as a novel technology to provide spectrum-efficient transportation. In order to study the performance of the BV optical networks, we propose a BV ext...
