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Open AccessS100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell–cell interactions with adjacent breast cancer cells
To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, we performed direct co-culture of non-tumorigenic mammary epithelial MCF10A cells and various breast cancer c...
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Role of tRNAs in Breast Cancer Regulation
Increased proliferation and protein synthesis are characteristics of transformed and tumor cells. Although the components of the translation machinery are often dysregulated in cancer, the role of tRNAs in can...
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Open AccessSingle-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer
Aminoacyl-tRNA synthetase-interacting multifunctional protein 2 (AIMP2) is a non-enzymatic component required for the multi-tRNA synthetase complex. While exon 2 skip** alternatively spliced variant of AIMP2...
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Aminoacyl-tRNA synthetases as therapeutic targets
Aminoacyl-tRNA synthetases (ARSs) are essential enzymes for protein synthesis with evolutionarily conserved enzymatic mechanisms. Despite their similarity across organisms, scientists have been able to generat...
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Open AccessControl of leucine-dependent mTORC1 pathway through chemical intervention of leucyl-tRNA synthetase and RagD interaction
Leucyl-tRNA synthetase (LRS) is known to function as leucine sensor in the mammalian target of rapamycin complex 1 (mTORC1) pathway. However, the pathophysiological significance of its activity is not well und...
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Correction: Corrigendum: Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection
Nature Microbiology 2, 16191 (2016); published online 17 October 2016; corrected 23 January 2017 In the original version of this Article, three author names were spelt incorrectly. The three names have now bee...
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Secreted tryptophanyl-tRNA synthetase as a primary defence system against infection
The N-terminal truncated form of a protein synthesis enzyme, tryptophanyl-tRNA synthetase (mini-WRS), is secreted as an angiostatic ligand. However, the secretion and function of the full-length WRS (FL-WRS) r...
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Article
Open AccessIntegrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers
Despite the explosion in the numbers of cancer genomic studies, metastasis is still the major cause of cancer mortality. In breast cancer, approximately one-fifth of metastatic patients survive 5 years. Theref...
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Association of Aminoacyl-tRNA Synthetases with Cancer
Although aminoacyl-tRNA synthetases (ARSs) and ARS-interacting multi-functional proteins (AIMPs) have long been recognized as housekee** proteins, evidence indicating that they play a key role in regulating ...
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Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
Beyond its canonical role in translation, lysyl-tRNA synthetase (KRS) stabilizes the prometastatic 67-kDa laminin receptor (67LR) in the plasma membrane. A small-molecule inhibitor of the KRS-67LR interaction ...
