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Article
Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry
Ovarian cancer is recognized with high mortality due to asymptomatic nature of the disease and difficulties in diagnosing early stage of the cancer. The present study evaluates the use of differential scanning...
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Article
Effects of thermal and mechanical stress on the physical stability of human growth hormone and epidermal growth factor
Thermal and mechanical stress conditions were applied to two model proteins, human growth hormone (hGH) and epidermal growth factor (EGF), to evaluate protein stability during the manufacturing process, focusi...
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Article
Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles
This study was to evaluate the pharmacokinetics and bioequivalence of two tacrolimus formulations which had different in vitro drug release profiles. Dynamic solubility, in vitro dissolution profiles of the t...
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Article
Investigation of polymeric excipients for dutasteride solid dispersion and its physicochemical characterization
To investigate the effects of polymeric excipients for dutasteride solid dispersion, experimental approaches together with physical interactions at molecular level were evaluated. The drug and various polymers...
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Article
Optimization of protein solution by a novel experimental design method using thermodynamic properties
In this study, the structural stability of hen egg white lysozyme in solution at various pH levels and in different types of buffers, including acetate, phosphate, histidine, and Tris, was investigated by mean...
