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Article
Dissociation mechanics and stability of type A botulinum neurotoxin complex by means of biophysical evaluation
Biophysical characterisation of type A botulinum neurotoxin (BoNT/A) could be challenging since it exists in association with neurotoxin associated proteins (NAPs) as large protein complexes. The objective of ...
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Article
Comparison of solubility enhancement by solid dispersion and micronized butein and its correlation with in vivo study
Even though butein can be a promising candidate for anti-inflammatory and anti-diabetic activities, it is poorly soluble limiting its availability for product development. Size reduction and solid dispersion (...
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Article
Rapid methodology for basal system selection of therapeutic proteins during the early stage biopharmaceutical development
This study aimed to introduce a quick method for develo** formulations during the early stages of biopharmaceutical drug development, starting from the isoelectric point (pI).
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Article
Process cycle development of freeze drying for therapeutic proteins with stability evaluation
Many therapeutic proteins have been launched in market or gone into development stages for their high therapeutic efficacy. The proteins can be developed mainly as liquid or solid dosage forms; pre-filled syri...
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Article
Investigation of early and advanced stages in ovarian cancer using human plasma by differential scanning calorimetry and mass spectrometry
Ovarian cancer is recognized with high mortality due to asymptomatic nature of the disease and difficulties in diagnosing early stage of the cancer. The present study evaluates the use of differential scanning...
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Article
Effects of thermal and mechanical stress on the physical stability of human growth hormone and epidermal growth factor
Thermal and mechanical stress conditions were applied to two model proteins, human growth hormone (hGH) and epidermal growth factor (EGF), to evaluate protein stability during the manufacturing process, focusi...
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Article
Bioequivalence of tacrolimus formulations with different dynamic solubility and in-vitro dissolution profiles
This study was to evaluate the pharmacokinetics and bioequivalence of two tacrolimus formulations which had different in vitro drug release profiles. Dynamic solubility, in vitro dissolution profiles of the t...
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Article
Evaluation of protein formulation and its viscosity with DSC, DLS, and microviscometer
The viscosity of highly concentrated protein solutions was evaluated using lysozyme as model protein. Viscosity profiles of lysozyme were examined with the effect of buffer and pH-value at various concentratio...
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Article
Investigation of polymeric excipients for dutasteride solid dispersion and its physicochemical characterization
To investigate the effects of polymeric excipients for dutasteride solid dispersion, experimental approaches together with physical interactions at molecular level were evaluated. The drug and various polymers...
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Article
Optimization of protein solution by a novel experimental design method using thermodynamic properties
In this study, the structural stability of hen egg white lysozyme in solution at various pH levels and in different types of buffers, including acetate, phosphate, histidine, and Tris, was investigated by mean...
