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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice
Asthma, the most prevalent respiratory disease, affects more than 300 million people and causes more than 250,000 deaths annually. Type 2-high asthma is characterized by interleukin (IL)-5-driven eosinophilia,...
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Open AccessRetraction Note: Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade
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Article
Single machine scheduling problems with truncated learning effects and exponential past-sequence-dependent delivery times
This paper studies the single machine scheduling problems with truncated logarithm processing times and exponential past-sequence-dependent delivery times. We prove that the makespan and total completion time ...
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Open AccessThe mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation
Umbilical cord-derived mesenchymal stem cell (UCMSC) transplantation has been deeply explored for premature ovarian insufficiency (POI) disease. However, the associated mechanism remains to be researched. To e...
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Article
Two-phase closed thermosyphon-induced frost jacking of piles and foundation instability in a thawed permafrost area
Two-phase closed thermosyphon (TPCT) is widely used to cool foundation soil and improve the stability of structures in cold regions. However, along with the cooling of soil surrounding a TPCT, frost heaving of...
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Article
Open AccessEnhanced pericyte-endothelial interactions through NO-boosted extracellular vesicles drive revascularization in a mouse model of ischemic injury
Despite improvements in medical and surgical therapies, a significant portion of patients with critical limb ischemia (CLI) are considered as “no option” for revascularization. In this work, a nitric oxide (NO...
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Article
Open AccessEffect of fermented dandelion on productive performance, meat quality, immune function, and intestinal microbiota of broiler chickens
Dandelion has a great potential to be used as feed additive. Using microbial fermentation technology to degrade cell walls is conducive to enable better release of bioactive compounds of dandelion. This study ...
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Open AccessClinical features and prognosis of pregnancy-related renal damage and pregnancy after chronic kidney disease
To explore the clinical features of renal damage related to pregnancy and pregnancy after chronic kidney disease (CKD), providing clinical evidence for the relationship between renal damage and pregnancy.
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Article
Institutional Investor Information Competition and Accounting Information Transparency: Implications for Financial Markets and Corporate Governance in China
This paper investigates the interrelationship between institutional investors’ information competition, accounting information transparency, and corporate governance in the context of Chinese A-share listed co...
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Article
Electrochemical biomimetic enzyme cascade amplification combined with target-induced DNA walker for detection of thrombin
Fe–N-doped carbon nanomaterials (Fe–N/CMs) were designed as a novel biomimetic enzyme with excellent peroxidase-like activity to achieve high-efficient enzyme cascade catalytic amplification with the aid of gl...
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Article
Carrier-free programmed spherical nucleic acid for effective ischemic stroke therapy via self-delivery antisense oligonucleotide
Antisense oligonucleotide (ASO) for anti-apoptosis is emerging as a highly promising therapeutic agents for ischemic stroke with complex pathological environment. However, its therapeutic efficacy is seriously...
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Article
Hypothalamic Grb10 enhances leptin signalling and promotes weight loss
Leptin acts on hypothalamic neurons expressing agouti-related protein (AgRP) or pro-opiomelanocortin (POMC) to suppress appetite and increase energy expenditure, but the intracellular mechanisms that modulate ...
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Article
Open AccessMass testing and characterization of 20-inch PMTs for JUNO
Main goal of the JUNO experiment is to determine the neutrino mass ordering using a 20 kt liquid-scintillator detector. Its key feature is an excellent energy resolution of at least 3% at 1 MeV, for which its ...
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Open AccessHuman loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior
Serotonin reuptake inhibitors and receptor agonists are used to treat obesity, anxiety and depression. Here we studied the role of the serotonin 2C receptor (5-HT2CR) in weight regulation and behavior. Using exom...
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Open AccessCell-cell contact-driven EphB1 cis- and trans- signalings regulate cancer stem cells enrichment after chemotherapy
Reactivation of chemotherapy-induced dormant cancer cells is the main cause of relapse and metastasis. The molecular mechanisms underlying remain to be elucidated. In this study, we introduced a cellular model...
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Open AccessRetraction Note: Effects of hPMSCs on granulosa cell apoptosis and AMH expression and their role in the restoration of ovary function in premature ovarian failure mice
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Article
Open AccessSK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis
Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood.
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Open AccessRetraction Note: hPMSC transplantation restoring ovarian function in premature ovarian failure mice is associated with change of Th17/Tc17 and Th17/Treg cell ratios through the PI3K/Akt signal pathway
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Open AccessRETRACTED ARTICLE: Copper-based metal–organic framework impedes triple-negative breast cancer metastasis via local estrogen deprivation and platelets blockade
Metastasis is one of the main causes of failure in the treatment of triple-negative breast cancer (TNBC). Abnormally estrogen level and activated platelets are the key driving forces for TNBC metastasis. Herei...
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Article
Publisher Correction: A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice
