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Article
Open AccessDevelopment and validation of a new model for the early diagnosis of tuberculous meningitis in adults based on simple clinical and laboratory parameters
The differential diagnosis between tuberculous meningitis (TBM) and viral meningitis (VM) or bacterial meningitis (BM) remains challenging in clinical practice, particularly in resource-limited settings. This ...
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Article
Open AccessChanges and significance of vascular endothelial injury markers in patients with diabetes mellitus and pulmonary thromboembolism
To investigate the changes and clinical significance of vascular endothelial injury markers in type 2 diabetes mellitus (T2DM) complicated with pulmonary embolism (PE).
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Article
Open AccessThe relationship between home-based physical activity and general well-being among Chinese university students during the COVID-19 pandemic: the mediation effect of self-esteem
This study aimed to investigate the mediating effect of self-esteem on the relationship between home-based physical activity and the general well-being of university students. A web-based questionnaire survey ...
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Article
Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis
Circular RNAs (circRNAs) play vital roles in various types of cancer and chemosentivity. In the progression of carcinogenesis, exosomes are messengers for intercellular communication. The aim of this study was...
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Article
Open AccessGASC1 promotes hepatocellular carcinoma progression by inhibiting the degradation of ROCK2
Hepatocellular carcinoma (HCC) is a devastating malignancy without targeted therapeutic options. Our results indicated that the histone demethylase GASC1 signature is associated with later tumor stage and poor...
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Article
Nucleation and crystallization of poly(propylene 2,5-furan dicarboxylate) by direct blending of microcrystalline cellulose: improved tensile and barrier properties
Poly(propylene 2,5-furan dicarboxylate) (PPF) is an example of alipharomatic bio-based polyester which has a high potential for the replacement of its fossil-based terephthalate counterparts (PPT). PPF offers ...
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Article
Association of toll-like receptor gene polymorphisms and its interaction with HPV infection in determining the susceptibility of cervical cancer in Chinese Han population
The aim of the study is to investigate the association of several single-nucleotide polymorphisms (SNPs) within Toll-like receptors (TLRs) gene and additional gene–gene and gene–human papillomavirus (HPV) infecti...
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Article
High pretreatment serum C-reactive protein level predicts a poor prognosis for combined small-cell lung cancer
High serum C-reactive protein (CRP) level is related to poor prognosis in several tumors. The aim of this study was to explore the prognosis value of serum CRP in patients with combined small-cell lung cancer ...
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Article
Open AccessThe clinical significance of preoperative plasma fibrinogen level and platelet count in resectable esophageal squamous cell carcinoma
Patients with malignant disease frequently present with activated coagulation pathways, which are potentially associated with tumor progression and prognosis. The aims of the study were to investigate the clin...
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Article
Open AccessWnt signaling is involved in 6-benzylthioinosine-induced AML cell differentiation
We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In thi...
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Article
Voxelwise meta-analysis of white matter abnormalities in progressive supranuclear palsy
White matter deficits constitute one element of the network dysfunction that underlies progressive supranuclear palsy (PSP). Cumulative evidence of white matter abnormalities in patients with PSP has been repo...
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Article
Notch1 signaling is irresponsible to the anti-leukemic effect of HDACis in B-ALL Nalm-6 cells
B cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematologic malignancy with limited treatment strategies. Histone deacetylases inhibitors (HDACis) are promising novel tools for cancer therapy, who...
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Article
Screening of Candida utilis and medium optimization for co-production of S-adenosylmethionine and glutathione
An effective S-adenosylmethionine and glutathione enriching yeast mutant of Candida utilis CCTCC M 209298 was first screened from plates containing 0.5 g/L of DL-ethionine by complex mutagenesis with UV and γ-ray...
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Article
A novel strategy on the high-cell-density cultivation of Candida utilis for the enhanced production of glutathione
Efficient glutathione production by high-cell-density cultivation of Candida utilis was investigated. A series of batch glutathione fermentations were carried out and the optimal initial glucose concentration was...
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Article
Saccades elicit obligatory allocation of visual working memory
In daily life, visual working memory (VWM) typically works in contexts in which people make frequent saccades. Here, we investigated whether people can effectively control the allocation of VWM when making a s...
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Article
A novel beta-propeller phytase from Pedobacter nyackensis MJ11 CGMCC 2503 with potential as an aquatic feed additive
A phytase with high activity at neutral pH and typical water temperatures (∼25°C) could effectively hydrolyze phytate in aquaculture. In this study, a phytase-producing strain, Pedobacter nyackensis MJ11 CGMCC 25...
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Article
A novel phytase from Yersinia rohdei with high phytate hydrolysis activity under low pH and strong pepsin conditions
Two novel phytase genes belonging to the histidine acid phosphatase family were cloned from Yersinia rohdei and Y. pestis and expressed in Pichia pastoris. Both the recombinant phytases had high activity at pH 1....
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Article
High-level expression of a truncated 1,3-1,4-β-d-glucanase from Fibrobacter succinogenes in Pichia pastoris by optimization of codons and fermentation
1,3-1,4-β-d-glucanase is an important endoglycosidase in the brewing and animal feed industries. To achieve high-level expression of recombinant glucanase in Pichia pastoris, we designed sequences encoding the α-...
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Article
Utilization of a spiropyran derivative in a polymeric film optode for selective fluorescent sensing of zinc ion
A new spiropyran derivative was synthesized and first utilized in a polymeric film-based optical sensor for zinc ion. Spiropyrans, combining the characteristics of metal binding and signal transduction, show p...
