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  1. Article

    Open Access

    Cryo-EM analysis of the T3S injectisome reveals the structure of the needle and open secretin

    The bacterial type III secretion system, or injectisome, is a syringe shaped nanomachine essential for the virulence of many disease causing Gram-negative bacteria. At the core of the injectisome structure is ...

    J. Hu, L. J. Worrall, C. Hong, M. Vuckovic, C. E. Atkinson… in Nature Communications (2018)

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    Article

    Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body

    The authors report the structure of the assembled membrane spanning ring forming proteins of the Salmonella Typhimurium injectisome basal body, including the first atomic structure of a member of the secretin fam...

    L. J. Worrall, C. Hong, M. Vuckovic, W. Deng, J. R. C. Bergeron, D. D Majewski… in Nature (2016)

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    Article

    Molecular docking programs successfully predict the binding of a β-lactamase inhibitory protein to TEM-1 β-lactamase

    Crystallization of the 1:1 molecular complex between the β-lactamase TEM-1 and the β-lactamase inhibitory protein BLIP has provided an opportunity to put a stringent test on current protein-docking algorithms....

    N.C.J. Strynadka, M. Eisenstein, E. Katchalski-Katzir… in Nature Structural Biology (1996)