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Article
Open AccessMorfofunctional and Molecular Changes in Placenta and Peripheral Blood in Preeclampsia and Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) and preeclampsia (PE) are common pregnancy complications with similar risk factors. Although GDM is associated with PE, the exact mechanism underlying the association is unc...
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Article
Open AccessRegulation of the Placental Renin-Angiotensin-Aldosterone System in Early- and Late-Onset Preeclampsia
Preeclampsia (PE) is one of the most dangerous complications of pregnancy, characterized by hypertension, proteinuria, and symptoms of multiple organ failure, which are detected de novo after 20 weeks of pregn...
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Article
Telocytes in the Myocardium of Children with Congenital Heart Disease Tetralogy of Fallot
Telocytes, a new type of interstitial stem cells with long thin processes that form a three-dimensional network around cardiomyocytes, vessels, and nerve fibers were described in the myocardium of children wit...
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Article
Enhanced Expression of TLR8 in Placental Tissue in Preeclampsia
The expression of TLR8 in the placental tissue was studied in specimens from women of reproductive age with early- and late-onset preeclampsia (12 and 8 patients, respectively). The reference groups included 1...
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Article
Content of Free Fetal DNA in Maternal Blood and Expression of DNA Recognition Receptors ZBP-1 in Placental Tissue in Preeclampsia and Preterm Labor
We evaluated the content of cell-free fetal DNA in maternal blood and expression of ZBP-1 receptors in the placental tissue of women with uncomplicated pregnancy, preeclampsia, and preterm labor. The study inc...
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Article
Peculiarities of RIG-1 Expression in Placental Villi in Preeclampsia
The expression of RIG-1 in placenta samples was assessed in women of reproductive age with early- and late-onset preeclampsia and cesarean delivery at 27-39 weeks of gestation. The highest expression of RIG-1 was...
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Article
Peculiarities of the Expression of TLR4 and Inhibitor of TLR-Cascade Tollip in the Placenta in Earlyand Late-Onset Preeclampsia
We studied the peculiarities of the expression of TLR4 and its inhibitor Tollip in placentas obtained from women aged 23-40 years with early- and late-onset preeclampsia. Histological examination of placental ...
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Article
Expression of Toll-Like Receptors in the Early Prenatal Development of the Human Retina
The expression of Toll-like receptors TLR2 and TLR4 in the human retina during early prenatal development is shown for the first time. It was found that the development and differentiation of the retina is acc...
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Article
Change in OncomicroRNA Expression in the Placenta during Preeclampsia
The expression of microRNA-17, microRNA-181a, and microRNA-519a in the villous tree in preeclampsia was analyzed using chromogenic in situ hybridization technique (CISH). It was found that in early-onset preeclam...
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Article
Dynamics of Renin, Angiotensin II, and Angiotensin (1–7) during Pregnancy and Predisposition to Hypertension-Associated Complications
Changes in the levels of rennin, angiotensin II, and angiotensin (1–7) were studied during normal pregnancy. The blood was taken on gestation days 140-237 and 238-280. No significant changes in renin concentra...
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Article
DAI-1 Receptor Expression in Placenta in Earlyand Late-Onset Preeclampsia
DAI-1 receptor (DNA-dependent activator of IFN-regulatory factors; DLM-1/ZBP-1) is an innate immunity cytoplasmic receptor of the DNA-recognition receptor class of antiviral immunity. DAI-1 expression reflects...
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Article
Expression of MicroRNA-146a and MicroRNA-155 in Placental Villi in Early- and Late-Onset Preeclampsia
We studied the expression of microRNA-146a and microRNA-155 in placental villi from 18 women (26-39 weeks of gestation) of reproductive age with early- or late-onset preeclampsia. The reference group consisted...
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Article
Ultrastructural Characteristics of Placental Telocytes
Telocytes of placental villi were studied by electronic microscopy during physiological pregnancy. Ultrastructural features of telocytes indicating their heterogeneity and presence of at least three types of v...
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Article
Conditions for Collection of Placental Tissue Samples for Culturing of Multipotent Mesenchymal Stromal Cells
Placentas from women aged 25-32 years with normal course of gestation were studied. It is essential to stick to certain methodological approaches for preparing viable multipotent mesenchymal stromal cell cultu...
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Article
The role of microRNA in regulation of the body’s immune responses
A complete characterization of microRNA (miRNA) and a scheme of its biogenesis are given. Special attention is paid to the involvement of miRNAs in the regulation of immune responses. It is implemented by thei...
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Article
Specific Features of TLR4 Expression in Structural Elements of Placenta in Patients with Preeclampsia
We studied the expression of TLR4 (Toll-like receptor 4) in the syncytiotrophoblast and vascular endothelial cells of terminal and stem placental villi in severe preeclampsia and normal pregnancy. In women of ...
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Article
Expression and Intracellular Localization of ACA and TRA-1-81 in Smooth Muscle Cell Tumors
We studied the expression and intracellular localization of ACA and TRA-1-81 in smooth muscle cell tumors. The study was performed on tissue specimens obtained during surgery from patients with uterine leiomyo...
