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Article
Reliable and developmentally appropriate study end points are needed to achieve drug development for treatment of pediatric pulmonary arterial hypertension
To identify suitable end points and surrogates for pediatric pulmonary arterial hypertension (PAH) as the lack of developmentally appropriate end point and clinical trials contribute to the unmet medical need.
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Article
Potassium currents of rat basilar artery smooth muscle cells
Primary isolates of smooth muscle cells from the basilar artery of the rat were studied using whole-cell and single-channel patch-clamp techniques. Two distinct potassium currents were characterized. With low ...
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Article
Excitability changes in the crustacean motor axon following activity
It has been shown experimentally that the crustacean motor axon is supernormally excitable following a train of action potentials (Zucker 1974). Such a phenomenon can lead to recruitment of terminals which are...
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Article
Solution of the Hodgkin-Huxley and cable equations on an array processor
This paper presents a method for the solution of equations for membrane ionic currents and the cable equation which describes the interaction of various segments in a compartmentalized model of the neuron. The...
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Article
Localized Ca2+and calcium-activated potassium conductances in terminals of a barnacle photoreceptor
Calcium channels are found in the presynaptic terminals of neurones, where they have a key role in synaptic transmission1. They are also found in the somata of many cells2, in dendrites3 and along a few axons2,4....
