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    Phase II study of sunitinib malate in patients with recurrent high-grade glioma

    Receptor tyrosine kinase signaling causes profound neo-angiogenesis in high-grade gliomas (HGG). The KIT, PDGFR-α, and VEGFR2 genes are frequently amplified and expressed in HGG and are molecular targets for ther...

    B. Neyns, J. Sadones, C. Chaskis, M. Dujardin, H. Everaert… in Journal of Neuro-Oncology (2011)