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  1. No Access

    Article

    Phase II study of sunitinib malate in patients with recurrent high-grade glioma

    Receptor tyrosine kinase signaling causes profound neo-angiogenesis in high-grade gliomas (HGG). The KIT, PDGFR-α, and VEGFR2 genes are frequently amplified and expressed in HGG and are molecular targets for ther...

    B. Neyns, J. Sadones, C. Chaskis, M. Dujardin, H. Everaert… in Journal of Neuro-Oncology (2011)

  2. No Access

    Article

    Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

    Although prostate cancer is the most common non-cutaneous malignancy diagnosed in men in the United States1,2, little is known about inherited factors that influence its genetic predisposition3,4,5. Here we repor...

    J. Carpten, N. Nupponen, S. Isaacs, R. Sood, C. Robbins, J. Xu… in Nature Genetics (2002)