20 Result(s)

Article

Registering the Kinetics of Intermolecular Interactions by Low-Coherence Interferometry for the Development of Biomarker Immunoassays for Cardiovascular Diseases

The quantitative monitoring of kinetic parameters for the interaction of biomolecules is demanded in many fields of fundamental and applied research. In this study, some compact biosensor devices, which are ch...

A. V. Orlov, D. O. Novichikhin, A. V. Pushkarev, Yu. A. Malkerov… in Doklady Physics (2022)

Article

Evidence of the Ferroelectric Polarization in Charge Transport through WTe₂ Weyl Semimetal Surface

We investigate electron transport along the surface of WTe₂ three-dimensional single crystals, which are characterized by the coexistence of the conductivity and ferroelectricity of a Weyl semimetal at room tempe...

N. N. Orlova, N. S. Ryshkov, A. V. Timonina, N. N. Kolesnikov… in JETP Letters (2021)

Article

Memory Effect in the Charge Transport in Strongly Disordered Antimony Films

We study conductivity of strongly disordered amorphous antimony films under high bias voltages. We observe non-linear current-voltage characteristic, where the conductivity value at zero bias is one of two dis...

N. N. Orlova, S. I. Bozhko, E. V. Deviatov in Journal of Experimental and Theoretical Ph… (2020)

Article

The Method of Hysteresis Properties Measurement for Magnetic Microwires under Stretching in Situ

Magnetic microwires are unique materials with a wide range of magnetic and high-frequency properties that are of considerable interest from the point of view of the application for magnetic sensors based on mi...

O. I. Aksenov, N. N. Orlova, A. S. Aronin in Instruments and Experimental Techniques (2019)

Article

Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia

Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acu...

N. N. Orlova, T. D. Lebedev, P. V. Spirin, V. S. Prassolov in Molecular Biology (2016)

Article

Comparative analysis of gene expression: Targeted antitumor therapy in neuroblastoma cell lines

In this study, we evaluated the level of c-kit, VEGFA, and MYC gene expression in seven neuroblastoma stable cell lines, i.e., SK-N-SH, SK-N-BE, SK-N-AS, SH-SY5Y, Kelly, IMR-32, and LAN-1. The level of expression...

T. D. Lebedev, P. V. Spirin, N. N. Orlova, M. M. Prokofjeva… in Molecular Biology (2015)

Article

Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling

The t(8;21)(q22;q22) rearrangement represents the most common chromosomal translocation in acute myeloid leukemia (AML). It results in a transcript encoding for the fusion protein AML1-ETO (AE) with transcript...

P V Spirin, T D Lebedev, N N Orlova, A S Gornostaeva, M M Prokofjeva… in Leukemia (2014)

Article

Universal modular system for in vitro screening of potential inhibitors of HIV-1 replication

A system based on recombinant lentiviral vectors has been designed for safe screening of potential anti-HIV drugs. The system can be used to evaluate the sensitivity of HIV-1 reverse transcriptase and integras...

M. M. Prokofjeva, N. N. Orlova, A. S. Gornostaeva, A. A. Shulgin… in Molecular Biology (2014)

Article

Dynamics of penetration of “Rigid” nanostructures of double-stranded DNA complexed with gadolinium into CHO cells

Currently, neutron capture therapy is a promising cancer treatment. This method is based on the reaction of thermal neutron capture by some nonradioactive elements (e.g., Gd¹⁵⁷), which results in the sub-sequent ...

V. I. Popenko, O. G. Leonova, V. I. Salyanov, N. N. Orlova… in Molecular Biology (2013)

Article

Expression of the FLT3-ITD oncogene sensitizes murine progenitor B-cell line BAF3 to cytotoxic action of binase

Acute myeloid leukemia makes up about 30% of all leukemia cases in adults. Mutations in the genes of the receptor tyrosine kinases KIT and FLT3, along with chromosomal translocations, are frequently found in l...

V. A. Mitkevich, N. N. Orlova, I. Yu. Petrushanko, O. V. Simonenko… in Molecular Biology (2013)

Article

RNA interference and deep sequencing as tools for identifying new genes involved in leukemogenesis

T. D. Lebedev, P. V. Spirin, N. N. Orlova… in Doklady Biochemistry and Biophysics (2013)

Article

Downregulation of activated leukemic oncogenes AML1-ETO and RUNX1(K83N) expression with RNA-interference

In the present study, we have applied the siRNA approach to reduce the expression of AML1-ETO and RUNX1(K83N) oncogenes, which are frequently found in leukemic cells. We have designed small hairpin RNAs (shRNA) f...

P. V. Spirin, D. Baskaran, N. N. Orlova, A. V. Rulina, N. A. Nikitenko… in Molecular Biology (2010)

Article

Characteristics of the coronary vasodilator reserve during partial restriction and subsequent restoration of the coronary blood flow

N. N. Orlova in Bulletin of Experimental Biology and Medicine (1986)

Article

Relationship between anaerobic energy formation and myocardial contractility during disturbance of coronary perfusion

R. A. Frol'kis, N. N. Orlova… in Bulletin of Experimental Biology and Medic… (1982)

Article

Correlation between the contractile function of the heart and the systemic hemodynamics in the early period of disturbance of the blood flow in a large coronary artery

N. N. Orlova in Bulletin of Experimental Biology and Medicine (1981)

Article

Influence of the various forms of molybdena on the adsorptive and catalytic (dehydrogenation and hydrogenolysis) properties of molybdena-alumina catalysts

The contents of three forms of molybdenum oxide compounds in molybdena-alumina catalysts have been determined by their solubility in water and ammonia. The form which is readily soluble in water and reducible ...

F. K. Shmidt, Kim En Khva, B. V. Timashkova… in Reaction Kinetics and Catalysis Letters (1980)

Article

Acid and complex-forming properties of antidiabetic sulfonylureas

N. N. Orlova, L. N. Khlaponina, V. V. Moroz in Pharmaceutical Chemistry Journal (1979)

Article

Application of several thermodynamic functions for characterizing structural changes in solutions of nonelectrolytes

I. V. Krasovskii, V. I. Makurina, N. N. Orlova in Theoretical and Experimental Chemistry (1976)