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Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?
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Meat intake and bladder cancer in a prospective study: a role for heterocyclic aromatic amines?
The suspect carcinogens, heterocyclic amines (HAAs), found in well-done meat require host-mediated metabolic activation before inducing DNA mutations. The role of SULT1A1 and of NAT2 on the activation of HAAs sug...
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Open AccessA case–control study of the impact of the East Anglian breast screening programme on breast cancer mortality
Although breast cancer screening has been shown to work in randomised trials, there is a need to evaluate service screening programmes to ensure that they are delivering the benefit indicated by the trials. We...
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Article
Open AccessFurther evidence for an HLA-related recessive mutation in nasopharyngeal carcinoma among the Chinese
We typed 247 cases of nasopharyngeal carcinoma (NPC), a disease predominantly of the southern Chinese, and 274 controls from the Chao Shan region of China's Guangdong province for HLA A and B. Besides confirmi...
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Article
Habitual fish consumption and glycated haemoglobin: The EPIC-Norfolk Study
Objective: To investigate the association between habitual fish consumption and a continuous measure of glycaemia.
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Article
Hip section modulus, a measure of bending resistance, is more strongly related to reported physical activity than BMD
We hypothesized that measures of physical activity would have a closer relationship with section modulus (SM), an indicator of bending resistance, than with bone mineral density (BMD) because physical activity...
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Article
Television viewing and low participation in vigorous recreation are independently associated with obesity and markers of cardiovascular disease risk: EPIC-Norfolk population-based study
Objective: This study describes the associations between sedentary behaviour (television viewing) and participation in vigorous recreational activity with obesity and with biomarkers of cardiovascular disease (CV...
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Open AccessThe NHS breast cancer screening programme
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Effects of dietary nutrients and food groups on bone loss from the proximal femur in men and women in the 7th and 8th decades of age
We measured the impact of diet, anthropometry, physical activity and lifestyle variables on rates of hip bone mineral density (BMD) loss in 470 white men and 474 white women aged 67–79 years at recruitment dwe...
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Open AccessExposure to power frequency electric fields and the risk of childhood cancer in the UK
The United Kingdom Childhood Cancer Study, a population-based case–control study covering the whole of Great Britain, incorporated a pilot study measuring electric fields. Measurements were made in the homes o...
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Article
A comprehensive model for familial breast cancer incorporating BRCA1, BRCA2 and other genes
In computing the probability that a woman is a BRCA1 or BRCA2 carrier for genetic counselling purposes, it is important to allow for the fact that other breast cancer susceptibility genes may exist. We used da...
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Article
Open AccessRisk factors for squamous cell carcinoma of the oesophagus in women: a case–control study
Oesophageal cancer rates in women in the UK are more than 3 times higher than in most other European populations. A population-based matched case–control study of histologically confirmed squamous cell carcino...
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Open AccessA case-control study of oesophageal adenocarcinoma in women: a preventable disease
The incidence of adenocarcinoma of the oesophagus in British women is among the highest in the world. To investigate its aetiology, we conducted a multi-centre, population based case–control study in four regi...
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Open AccessSomatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis
Many studies have investigated the association between alterations in the p53 gene and clinical outcome of breast cancer, and most investigators have reported poorer overall and disease-free survival (as indicate...
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Article
Nutrition and esophageal cancer
Epidemiologic evidence on the relation between nutrition and esophageal cancer is reviewed. Results from ecologic, case-control, cohort, and intervention studies are included. Most of the findings pertain more...
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Article
Decreased non-esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance
To investigate causes of increased triglyceride concentrations in subjects with normal glucose tolerance (determined by oral glucose tolerance testing using World Health Organization criteria) 883 healthy subj...
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Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids
Although plasma insulin and triglyceride concentrations are positively correlated in many studies, the relationships between insulin resistance, insulin secretion and hypertriglyceridaemia remain unclear. To s...
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Article
Height and glucose tolerance in adult subjects
In a prospective study concerning the pathogenesis of impaired glucose tolerance and Type 2 (non-insulindependent) diabetes mellitus, 346 subjects with no clinical history of diabetes were given a standard 75 ...
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A Preliminary Analysis of HLA Studies on Multiple NPC Cases among Siblings from the People’s Republic of China, Hongkong, Singapore and Malaysia
Earlier studies (1,2) have demonstrated an association between nasopharyngeal carcinoma (NPC) and the occurrence of HLA antigens BW46, B17 and A2. In (2), relative risks of NPC for the phenotypic expression of...
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Article
Evaluation of screening programmes for gynaecological cancer
A workshop of the Project on Evaluation of Screening Programmes of the International Union against Cancer (UICC) was held in Lyon, France. on November 20-22, 1984. The focus of the workshop was on screening fo...
