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Article
Open AccessEfficacy of RCI001 as a therapeutic candidate of dry eye disease in a modified mixed dry eye model
To evaluate the therapeutic effects of topical RCI001 (RCI) and compare its efficacy with that of 1% prednisolone acetate (PDE) and 5% Lifitegrast in a modified mixed dry eye disease (DED) model.
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Article
Open AccessExogenous 8-hydroxydeoxyguanosine attenuates doxorubicin-induced cardiotoxicity by decreasing pyroptosis in H9c2 cardiomyocytes
Doxorubicin (DOX), which is widely used in cancer treatment, can induce cardiomyopathy. One of the main mechanisms whereby DOX induces cardiotoxicity involves pyroptosis through the NLR family pyrin domain con...
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Article
Value of shear wave elastography during second-look breast ultrasonography for suspicious lesions on magnetic resonance imaging
This study aimed to determine whether the addition of shear wave elastography (SWE) helps to improve diagnostic performance of second-look ultrasonography (SLUS) for suspicious lesions on magnetic resonance im...
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Article
Open AccessMultidetector CT findings of primary pleural angiosarcoma : a systematic review, an additional cases report
To demonstrate and analyze the relatively common imaging findings in this rare primary pleural angiosarcoma (PPA).
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Article
Open AccessComparison of therapeutic effects between topical 8-oxo-2′-deoxyguanosine and corticosteroid in ocular alkali burn model
We compared the therapeutic effects of topical 8-oxo-2′-deoxyguanosine (8-oxo-dG) and corticosteroid in a murine ocular alkali burn model. (n = 128) The corneal alkali burn model was established by applying 0....
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Article
The value of primary tumor 18F-FDG uptake on preoperative PET/CT for predicting intratumoral lymphatic invasion and axillary nodal metastasis
The preoperative evaluation of axillary lymph node (LN) status is important for prognostic prediction of breast cancer. We investigated the ability of 18F-fluorodeoxyglucose positron emission tomography/computed ...
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Article
Open AccessComparison of coronary computed tomography angiography image quality with high- and low-concentration contrast agents (CONCENTRATE): study protocol for a randomized controlled trial
With the development of computed tomography (CT) technology, coronary CT angiography can be acquired with low doses of radiation and contrast agent without a loss of diagnostic performance. The primary objecti...
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Article
Giant cell tumor with secondary aneurysmal bone cyst: A unique presentation with an ossified extraosseous soft tissue mass
The authors describe a case of giant cell tumor (GCT) with secondary aneurysmal bone cyst (ABC) in a 44-year-old man with chronic, intermittent knee pain. A unique feature is the presentation of GCT with an os...
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Article
Emphasis on the MR imaging findings of brown tumor: a report of five cases
Brown tumors are focal reactive osteolytic lesions that are encountered in patients with primary or secondary hyperparathyroidism, and these tumors have nonspecific magnetic resonance (MR) imaging findings. Ho...
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Article
Open AccessLYR71, a derivative of trimeric resveratrol, inhibits tumorigenesis by blocking STAT3-mediated matrix metalloproteinase 9 expression
Tumor migration/invasion is the main cause of tumor progression and STAT3 is needed to enhance tumor migration/invasion by up-regulating MMP-9. Thus, agents that inhibit STAT3 activation may be used as an anti...
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Article
Open AccessSTAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination
Hypoxia-inducible factor 1α (HIF-1α) is rapidly degraded by the ubiquitin-proteasome pathway under normoxic conditions. Ubiquitination of HIF-1α is mediated by interaction with von Hippel-Lindau tumor suppress...
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Article
8-Hydroxydeoxyguanosine induces senescence-like changes in KG-1, human acute myelocytic leukemia cell line
8-Hydroxydeoxyguanosine (oh8dG) treatment induced senescence-like changes in KG-1 cells, a human acute myelocytic leukemia cell line. The oh8dG-treated cells stained positive for senescence associated β-galactosi...
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Article
Open AccessAnti-inflammatory effects of 8-hydroxydeoxyguanosine in LPS-induced microglia activation: suppression of STAT3-mediated intercellular adhesion molecule-1 expression
To elucidate the roles of 8-hydroxydeoxyguanosine (oh8dG), the nucleoside of 8-hydroxyguanine (oh8Gua), we examined the effects of oh8dG upon LPS-induced intercellular adhesion molecule-1 (ICAM-1) expression and ...
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Article
Sacrococcygeal chordoma: MR imaging in 30 patients
To evaluate MR imaging of sacrococcygeal chordoma.
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Article
Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity
Bcl-2 stimulates mutagenesis after the exposure of cells to DNA-damaging agents. However, the biological mechanisms of Bcl-2-mediated mutagenesis have remained largely obscure. Here we demonstrate that the Bcl...
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Article
Open AccessBase excision repair synthesis of DNA containing 8-oxoguanine in Escherichia coli
8-oxo-7,8-dihydroguanine (8-oxo-G) in DNA is a mutagenic adduct formed by reactive oxygen species. In Escherichia coli, 2,6-dihydroxy-5N-formamidopyrimidine (Fapy)-DNA glycosylase (Fpg) removes this mutagenic ...
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Article
Open AccessExpression of hOGG1 protein during differentiation of HL-60 cells
Human 8-oxo-G-DNA glycosylase 1 (hOGG1) is a DNA glycosylase to cleave 8-oxo-7,8-dihydroguanine (8-oxo-G), a mutagenic DNA adduct formed by oxidant stresses. Here, we examined hOGG1 protein expression and repa...
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Article
Open AccessIdentification of Escherichia coli 8-oxoguanine endonuclease
7,8-Dihydro-8-oxoguanine (oh8Gua) endonuclease is a DNA repair enzyme in Escherichia coli to remove oh8Gua, a promutagenic DNA adduct. Due to the unique mode of enzyme action and substrate specificity, this DN...
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Article
Leukemic cell line, KG-1 has a functional loss of hOGG1 enzyme due to a point mutation and 8-hydroxydeoxyguanosine can kill KG-1
We tested the cytotoxic action of 8-hydroxyguanine (8ohG) by observing the viability of several leukemic cell lines (KG-1, U937, Jurkat and K 562) in the presence of 8-hydroxydeoxyguanosine (8ohdG), a nucleosi...
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Article
Reactive Oxygen Species-specific Mechanisms of Drug Resistance in Paraquat-resistant Acute Myelogenous Leukemia Sublines
Reactive oxygen species (ROS)-specific mechanisms of drug resistance were explored in paraquat (PQ)-resistant acute myelogenous leukemia cell (OCI/AML-2) sublines. For this, PQ-resistant AML sublines, AML-2/PQ...
