Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges
Focus on Leprosy, Leishmaniasis, Melioidosis and Tuberculosis
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Myron Christodoulides
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Article
Immunization with recombinant LiHyp1 protein plus adjuvant is protective against tegumentary leishmaniasis
Tegumentary leishmaniasis (TL) is the main clinical manifestation of leishmaniasis, and it can cause the infected hosts to self-healing cutaneous lesions until mutilating scars in mucosal membranes, particular...
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Article
Open AccessDevelopment of an Affordable ELISA Targeting the SARS-CoV-2 Nucleocapsid and Its Application to Samples from the Ongoing COVID-19 Epidemic in Ghana
The true nature of the population spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in populations is often not fully known as most cases, particularly in Africa, are asymptomatic. Finding...
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Article
Open AccessA urine-based ELISA with recombinant non-glycosylated SARS-CoV-2 spike protein for detecting anti-SARS-CoV-2 spike antibodies
Serological assays have been widely used to detect anti-SARS-CoV-2 antibodies, which are generated from previous exposure to the virus or after vaccination. The presence of anti-SARS-CoV-2 Nucleocapsid antibod...
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Chapter
Introduction
Neglected Tropical Diseases (NTDs) are caused by a diversity of pathogens including viruses, bacteria, parasites, fungi, and toxins, which affect 2–3 billion people globally who live in the least developed cou...
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Chapter
Vaccines for Canine Leishmaniasis
Visceral leishmaniasis is a zoonotic disease in many countries and dogs are considered the main domestic reservoir of Leishmania parasites, and the presence of infected animals represents a potential risk for hum...
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Book
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Open AccessDevelopment of a multicellular in vitro model of the meningeal blood-CSF barrier to study Neisseria meningitidis infection
Bacterial meningitis is a life-threatening disease that occurs when pathogens such as Neisseria meningitidis cross the meningeal blood cerebrospinal fluid barrier (mBCSFB) and infect the meninges. Due to the huma...
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Protocol
In Silico Design of Recombinant Chimera T Cell Peptide Epitope Vaccines for Visceral Leishmaniasis
Visceral leishmaniasis (VL) is a neglected tropical disease caused by protozoan parasites of the genus Leishmania. Systemic VL is fatal if untreated and there are no prophylactic human vaccines available. Several...
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Protocol
Preclinical Assessment of the Immunogenicity of Experimental Leishmania Vaccines
Leishmaniases are neglected diseases caused by Leishmania parasites and affect millions of people worldwide. The induction of protective immunity against infection by some species of Leishmania has stimulated the...
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Article
ChimLeish, a new recombinant chimeric protein evaluated as a diagnostic and prognostic marker for visceral leishmaniasis and human immunodeficiency virus coinfection
Visceral leishmaniasis (VL) is a neglected tropical disease of global importance caused by parasites of the genus Leishmania, and coinfection with human immunodeficiency virus (HIV) is common in countries where b...
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Article
Open AccessAuthor Correction: Morphological and cytokine profiles as key parameters to distinguish between Gram-negative and Gram-positive bacterial keratitis
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Chapter
Toll-Like Receptor 4 Interactions with Neisseria
Neisseria meningitidis (meningococcus) causes meningitis and sepsis and Neisseria gonorrhoeae (gonococcus) causes the sexually transmitted disease gonorrhoea. Both pathogens contain lipooligosaccharide (LOS) in t...
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Open AccessMorphological and cytokine profiles as key parameters to distinguish between Gram-negative and Gram-positive bacterial keratitis
Bacterial keratitis (BK) is an ocular disorder associated with poor visual prognosis. Quantification of the associated inflammatory response may provide insight into the pathogenesis of BK and guide treatment ...
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Article
Open AccessA candidate vaccine for human visceral leishmaniasis based on a specific T cell epitope-containing chimeric protein protects mice against Leishmania infantum infection
Leishmaniases are neglected diseases caused by infection with Leishmania parasites and there are currently no prophylactic vaccines. In this study, we designed in silico a synthetic recombinant vaccine against vi...
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Open AccessCharacterization of two putative Dichelobacter nodosus footrot vaccine antigens identifies the first lysozyme inhibitor in the genus
The Gram-negative anaerobic bacterium Dichelobacter nodosus (Dn) causes footrot in ruminants, a debilitating and highly contagious disease that results in necrotic hooves and significant economic losses in agricu...
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Book
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Protocol
Preparation of Lipooligosaccharide (LOS) from Neisseria gonorrhoeae
Neisseria gonorrhoeae is a gram-negative obligate human pathogen that contains lipooligosaccharide (LOS) as a major constituent within the outer membrane. LOS plays a major role in pathogenesis by inducing host i...
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Protocol
Basic Methods for Examining Neisseria gonorrhoeae Interactions with Host Cells In Vitro
The obligate human pathogen Neisseria gonorrhoeae colonizes primarily the mucosal columnar epithelium of the male urethra and the female endocervix. In addition, gonococci can infect the anorectal, pharyngeal, an...
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Protocol
Use of Human Fallopian Tube Organ in Culture (FTOC) and Primary Fallopian Tube Epithelial Cells (FTEC) to Study the Biology of Neisseria gonorrhoeae Infection
Epithelial cells represent one of the most important physical barriers to many bacterial pathogens. In the case of Neisseria gonorrhoeae, the epithelial cell response is critical because they are the main target ...
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Open AccessThe meninges as barriers and facilitators for the movement of fluid, cells and pathogens related to the rodent and human CNS
Meninges that surround the CNS consist of an outer fibrous sheet of dura mater (pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the arachnoid and pia mater (leptomeninges) ...
