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    Open Access

    Drug*placebo interaction effect may bias clinical trials interpretation: hybrid balanced placebo and randomized placebo-controlled design

    Conventional randomized placebo-controlled study design assumes the absence of drug*placebo interaction. We hypothesized the presence of such an interaction and that conventionally estimated drug effect might ...

    Muhammad M. Hammami, Safa Hammami, Reem Al-Swayeh in BMC Medical Research Methodology (2016)