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Untapped rich microbiota of mangroves of Pakistan: diversity and community compositions
The mangrove ecosystem is the world’s fourth most productive ecosystem in terms of service value and offering rich biological resources. Microorganisms play vital roles in these ecological processes, thus rese...
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Enoxaparin for COVID-19: a systematic review and meta-analysis of randomized controlled trials
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Open AccessCorrection to: Solitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta‑analysis
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Remediation of Environmental Contaminants Through Phytotechnology
Environmental pollution caused by organic pollutants, radionuclides, and potentially toxic elements (PTEs) affects the quality of the biosphere (water, air, and soil). Rapid industrial growth, mining, agricult...
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Metal Nanoparticles in the Field of Medicine and Pharmacology
One of the cutting-edge technologies that hold considerable promise for both medical and non-medical applications is metal nanoparticles. Metal nanoparticles are extremely active and have optical, electrical, ...
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Open AccessSolitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta-analysis
The debate on whether or not there is a difference in the incidence of thyroid cancer between the patients with Solitary thyroid Nodule (STN) and Multinodular Goiter (MNG) has been constantly present for the l...
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Open AccessThe cholera outbreak in Lahore, Pakistan: challenges, efforts and recommendations
The Punjab health authorities have declared a cholera outbreak with over 2000 acute diarrheal cases being reported in Lahore in April 2022 and 25 laboratory-confirmed cases as of 27 May 2022. Overpopulation, p...
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Foreign direct investment and economic growth nexus in the presence of domestic institutions: a regional comparative analysis
Foreign direct investment (FDI) inflow is seen as a major source of external financing and a key factor in promoting economic growth, whereas sound institutions’ quality (IQ) not only directly enhances the eco...
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Environmental concerns of financial inclusion and economic policy uncertainty in the era of globalization: evidence from low & high globalized OECD economies
Environmental consequences of financial aspects, policy uncertainties and rapid globalization is the topic of intense debate in present years. However, this study contribute to existing literature in an innova...
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Em14-3-3 delivered by PLGA and chitosan nanoparticles conferred improved protection in chicken against Eimeria maxima
Eimeria maxima (E. maxima) are an intracellular apicomplexan protozoan that causes intestinal coccidiosis in chickens. The purpose of this research was to develop a novel delivery approach for recombinant E. max...
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Open AccessProteomics analysis reveals that the proto-oncogene eIF-5A indirectly influences the growth, invasion and replication of Toxoplasma gondii tachyzoite
The proliferative stage (tachyzoite) of Toxoplasma gondii (T. gondii) is critical for its transmission and pathogenesis, and a proto-oncogene eukaryotic translation initiation factor (eIF-5A) plays an important r...
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Open AccessFasciola gigantica tegumental calcium-binding EF-hand protein 4 exerts immunomodulatory effects on goat monocytes
The liver fluke Fasciola gigantica secretes excretory-secretory proteins during infection to mediate its interaction with the host. In this study, we investigated the immunomodulatory effects of a recombinant teg...
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Open AccessMitochondrial genomes of two eucotylids as the first representatives from the superfamily Microphalloidea (Trematoda) and phylogenetic implications
The Eucotylidae Cohn, 1904 (Superfamily: Microphalloidea), is a family of digeneans parasitic in kidneys of birds as adults. The group is characterized by the high level of morphological similarities among gen...
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Open AccessCharacterization of a rhodanese homologue from Haemonchus contortus and its immune-modulatory effects on goat immune cells in vitro
Modulation of the host immune response by nematode parasites has been widely reported. Rhodaneses (thiosulfate: cyanide sulfurtransferases) are present in a wide range of organisms, such as archaea, bacteria, ...
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Open AccessUnveiling the immunomodulatory properties of Haemonchus contortus adhesion regulating molecule 1 interacting with goat T cells
Gastrointestinal nematodes could release excretory-secretory (ES) proteins into the host environment to ensure their survival. These ES proteins act as immunomodulators to suppress or subvert the host immune r...
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Open AccessIdentification of a novel methyltransferase-type 12 protein from Haemonchus contortus and its effects on functions of goat PBMCs
Methyltransferases (MTFs) are broad range of enzymes, which are ubiquitously expressed in diverse organisms ranging from bacteria to animals. MTFs proteins have been associated with various biological/cellular...
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Open AccessFacile synthesis of ternary graphene nanocomposites with doped metal oxide and conductive polymers as electrode materials for high performance supercapacitors
Supercapacitors (SCs) due to their high energy density, fast charge storage and energy transfer, long charge discharge curves and low costs are very attractive for designing new generation of energy storage de...
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Open AccessMolecular characterisation and the protective immunity evaluation of Eimeria maxima surface antigen gene
Coccidiosis is recognised as a major parasitic disease in chickens. Eimeria maxima is considered as a highly immunoprotective species within the Eimeria spp. family that infects chickens. In the present research,...
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Open AccessCharacterization of a secreted cystatin of the parasitic nematode Haemonchus contortus and its immune-modulatory effect on goat monocytes
Haemonchosis is a disease of the small ruminant caused by a nematode parasite Haemonchus contortus, and it is most important and alarming challenges to the small ruminant’s production. The infection of the H. con...
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Open AccessThe N- and C-terminal carbohydrate recognition domains of Haemonchus contortus galectin bind to distinct receptors of goat PBMC and contribute differently to its immunomodulatory functions in host-parasite interactions
Hco-gal-m is a tandem-repeat galectin isolated from the adult worm of Haemonchus contortus. A growing body of studies have demonstrated that Hco-gal-m could exert its immunomodulatory effects on host peripheral b...