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Article
Open AccessRemote Ischaemic Conditioning in STEMI Patients in Sub-Saharan AFRICA: Rationale and Study Design for the RIC-AFRICA Trial
Despite evidence of myocardial infarct size reduction in animal studies, remote ischaemic conditioning (RIC) failed to improve clinical outcomes in the large CONDI-2/ERIC-PPCI trial. Potential reasons include ...
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Article
Open AccessPrevalence and factors associated with dyslipidemia among adolescents in Saudi Arabia
Dyslipidemia is a major risk factor for atherosclerosis. Screening for dyslipidemia at an early age is essential to prevent and control its consequences. This study aimed to determine prevalence of dyslipidemi...
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Article
Higher serum alkaline phosphatase activity in infants born to vitamin D–deficient mothers
Our research shows that the newborns of vitamin D–deficient mothers have higher serum alkaline phosphatase (ALP) activity compared with those of vitamin D–non-deficient mothers, which is likely related to incr...
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Article
Open AccessAn assessment for diagnostic and therapeutic modalities for management of pediatric Iron defficiency Anemia in Saudi Arabia: a crossectional study
Iron deficiency anemia (IDA) is a global public health issue that affect more than 2 billion individuals worldwide. However evidence for optimal management of IDA is lacking.
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Article
Open AccessQuality of life among home healthcare patients in Saudi Arabia: household-based survey
The need for home healthcare programs is an increasingly becoming important common component of healthcare worldwide, as an alternative to hospitalization, owing to the growing elderly population, chronic and ...
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Article
Open AccessRisk factors for falls in older adults in a South African Urban Community
Studies on falls in older adults have mainly been conducted in high income countries. Scant, if any, information exists on risk factors for falls in the older population of sub-Saharan African countries.
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Article
Open AccessA single-blinded trial of methotrexate versus azathioprine as steroid-sparing agents in generalized myasthenia gravis
Long-term immunosuppression is often required in myasthenia gravis (MG). There are no published trials using methotrexate (MTX) in MG. The steroid-sparing efficacy of azathioprine (AZA) has been demonstrated a...
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Article
Open AccessLack of association between stavudine exposure and lipoatrophy, dysglycaemia, hyperlactataemia and hypertriglyceridaemia: a prospective cross sectional study
Stavudine continues to be widely used in resource poor settings despite its toxicity. Our objective was to determine association between plasma stavudine concentrations and lipoatrophy, concentrations of gluco...
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Article
Open AccessDifferent screening strategies (single or dual) for the diagnosis of suspected latent tuberculosis: a cost effectiveness analysis
Previous health economic studies recommend either a dual screening strategy [tuberculin skin test (TST) followed by interferon-γ-release assay (IGRA)] or a single one [IGRA only] for latent tuberculosis infect...
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Article
Open AccessThe mitochondrial DNA T16189C polymorphism and HIV-associated cardiomyopathy: a genotype-phenotype association study
The mitochondrial DNA (mtDNA) T16189C polymorphism, with a homopolymeric C-tract of 10–12 cytosines, is a putative genetic risk factor for idiopathic dilated cardiomyopathy in the African and British populatio...
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Article
Open AccessUtility of CD4 cell counts for early prediction of virological failure during antiretroviral therapy in a resource-limited setting
Viral load monitoring is not available for the vast majority of patients receiving antiretroviral therapy in resource-limited settings. However, the practical utility of CD4 cell count measurements as an alter...
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Article
Open AccessUtility of interferon-γ ELISPOT assay responses in highly tuberculosis-exposed patients with advanced HIV infection in South Africa
Interferon-gamma (IFN-γ) ELISPOT assays incorporating Mycobacterium tuberculosis-specific antigens are useful in the diagnosis of tuberculosis (TB) or latent infection. However, their utility in patients with adv...
