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  1. Article

    Open Access

    Prognostic value of OCT4A and SPP1C transcript variant co-expression in early-stage lung adenocarcinoma

    Octamer-binding transcription factor 4A (OCT4A) is essential for cell pluripotency and reprogramming both in humans and mice. To date, however, the function of human OCT4 in somatic and/or tumour tissues is la...

    Seijiro Koshimune, Mitsuko Kosaka, Nobuhiko Mizuno, Hiromasa Yamamoto in BMC Cancer (2020)

  2. No Access

    Chapter

    Multipotentiality of Iris Pigment Epithelial Cells in Vertebrate Eye

    The discovery of adult stem cells indicated a previously unrecognized degree of plasticity in stem cell function (1-3). Recent extensive studies have suggested that mammalian stem cells residing in one tissue may...

    Mitsuko Kosaka, Guangwei Sun, Masatoshi Haruta, Masayo Takahashi in Adult Stem Cells (2004)

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    Article

    Induction of photoreceptor-specific phenotypes in adult mammalian iris tissue

    We show that iris tissue in the adult rat eye, which is embryonically related to the neural retina, can generate cells expressing differentiated neuronal antigens. In addition, the Crx gene transfer induced the s...

    Masatoshi Haruta, Mitsuko Kosaka, Yumi Kanegae, Izumu Saito in Nature Neuroscience (2001)

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    Article

    The kinetics of induction of Hox1.6 and c-jun mRNA during three different ways of inducing differentiation in teratocarcinoma F9 cells

    Changes in Hox1.6 and c-jun gene expression were examined upon F9 cell differentiation that was induced by three independent methods: a drug treatment with retinoic acid (RA), that with sodium butyrate (NaB), ...

    Souichi A. Iwai, Yukio Nishina in In Vitro Cellular & Developmental Biology … (1995)