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9 Result(s)
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Misako Matsumoto
Cancer Research
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Article
Open AccessTumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy
Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...
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Chapter
Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy
Dendritic cells (DCs) initiate the maturation to a specific stage in response to stimuli with microbial pattern molecules (PAMP) and trigger activation of host immune response together with antigens (Ags). Rec...
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Book
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Chapter
Adjuvant Immunotherapy for Cancer: From Basic Research to Clinical Bench
Microbial infection is usually accompanied by inflammation and tissue wounding. These local symptoms are dependent on a host’s immune response rather than the direct cell damage by invading microbes. A microbe...
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Chapter
The Role of Innate Immune Signaling in Regulation of Tumor-Associated Myeloid Cells
Tumor progression is frequently associated with a profound alteration in myelopoiesis, which results in expansion of tumor-associated myeloid cells represented by tumor-associated macrophages and myeloid-deriv...
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Article
Open AccessErratum to: an embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
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Article
Open AccessAn embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...
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Article
The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer
Infection with RNA viruses presents a typical pattern of virus products, double-stranded RNA (dsRNA), and induces the maturation of antigen-presenting dendritic cell (mDC). There are several dsRNA sensors that...
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Article
A novel protein that participates in nonself discrimination of malignant cells by homologous complement
The human complement (C) system protects an individual against substances of nonself origin, including xenografts and microbial pathogens1. Human cells express C-regulatory proteins, CD46 and CD55, thereby circum...
