Page
%P
-
Article
Open AccessThe TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice
Intestinal tumorigenesis is promoted by myeloid differentiation primary response gene 88 (MyD88) activation in response to the components of microbiota in Apc Min/+
-
Article
Open AccessZyxin stabilizes RIG-I and MAVS interactions and promotes type I interferon response
RIG-I and MDA5 are cytoplasmic viral RNA sensors that belong to the RIG-I-like receptors (RLRs), which induce antiviral innate immune responses, including the production of type I interferon and other pro-infl...
-
Article
Double-stranded RNA promotes CTL-independent tumor cytolysis mediated by CD11b+Ly6G+ intratumor myeloid cells through the TICAM-1 signaling pathway
PolyI:C, a synthetic double-stranded RNA analog, acts as an immune-enhancing adjuvant that regresses tumors in cytotoxic T lymphocyte (CTL)-dependent and CTL-independent manner, the latter of which remains lar...
-
Article
Open AccessTumoricidal efficacy coincides with CD11c up-regulation in antigen-specific CD8+ T cells during vaccine immunotherapy
Dendritic cells (DCs) mount tumor-associated antigens (TAAs), and the double-stranded RNA adjuvant Poly(I:C) stimulates Toll-like receptor 3 (TLR3) signal in DC, which in turn induces type I interferon (IFN) a...
-
Article
Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers
Structural variations disrupting the 3′ region of PD-L1 are shown to aid immune evasion in a number of human cancers, including adult T-cell leukaemia/lymphoma, and in a mouse tumour model, CRISPR/Cas9-mediated d...
-
Article
Open AccessDouble-stranded RNA analog and type I interferon regulate expression of Trem paired receptors in murine myeloid cells
Triggering receptors expressed on myeloid cells (Trem) proteins are a family of cell surface receptors used to control innate immune responses such as proinflammatory cytokine production in mice. Trem genes be...
-
Chapter
Pattern Recognition by Dendritic Cells and Its Application to Vaccine Adjuvant for Antitumor Immunotherapy
Dendritic cells (DCs) initiate the maturation to a specific stage in response to stimuli with microbial pattern molecules (PAMP) and trigger activation of host immune response together with antigens (Ags). Rec...
-
Article
Defined TLR3-specific adjuvant that induces NK and CTL activation without significant cytokine production in vivo
Ligand stimulation of the Toll-like receptors (TLRs) triggers innate immune response, cytokine production and cellular immune activation in dendritic cells. However, most TLR ligands are microbial constituents...
-
Book
-
Chapter
Adjuvant Immunotherapy for Cancer: From Basic Research to Clinical Bench
Microbial infection is usually accompanied by inflammation and tissue wounding. These local symptoms are dependent on a host’s immune response rather than the direct cell damage by invading microbes. A microbe...
-
Chapter
The Role of Innate Immune Signaling in Regulation of Tumor-Associated Myeloid Cells
Tumor progression is frequently associated with a profound alteration in myelopoiesis, which results in expansion of tumor-associated myeloid cells represented by tumor-associated macrophages and myeloid-deriv...
-
Article
The N-terminal domain of TIR domain-containing adaptor molecule-1, TICAM-1
-
Article
Open AccessErratum to: an embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
-
Article
Toll-like receptor 3 recognizes incomplete stem structures in single-stranded viral RNA
Endosomal Toll-like receptor 3 (TLR3) serves as a sensor of viral infection and sterile tissue necrosis. Although TLR3 recognizes double-stranded RNA, little is known about structural features of virus- or hos...
-
Article
Multi-Step Regulation of Interferon Induction by Hepatitis C Virus
Acute hepatitis C virus (HCV) infection evokes several distinct innate immune responses in host, but the virus usually propagates by circumventing these responses. Although a replication intermediate double-st...
-
Article
Open AccessAn embryo-specific expressing TGF-β family protein, growth-differentiation factor 3 (GDF3), augments progression of B16 melanoma
Malignant tumor cells often express embryonic antigens which share the expression with embryonic stem (ES) cells. The embryonic antigens are usually encoded by ES cell-specific genes, a number of which are ass...
-
Article
The extrinsic RNA-sensing pathway for adjuvant immunotherapy of cancer
Infection with RNA viruses presents a typical pattern of virus products, double-stranded RNA (dsRNA), and induces the maturation of antigen-presenting dendritic cell (mDC). There are several dsRNA sensors that...
-
Article
Regulator of complement activation (RCA) gene cluster in Xenopus tropicalis
Genome and expressed sequence tag information of Xenopus tropicalis suggested that short-consensus repeat (SCR)-containing proteins are encoded by three genes that are mapped within a 300-kb downstream of PFKFB2,...
-
Article
Innate immune therapy with a Bacillus Calmette-Guérin cell wall skeleton after radical surgery for non-small cell lung cancer: A case-control study
We investigated whether adjuvant immunotherapy with Bacillus Calmette-Guérin (BCG) cell wall skeleton (CWS) and surgical resection was better than resection, with or without other adjuvant therapy, for patient...
-
Article
Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers
Background Toll-like receptors (TLRs) may play active roles in both innate and adaptive immune responses in human intrahepatic biliary epithelial cells (HIBECs). The role of TLR3 expresse...
