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Article
METTL3-modified lncRNA DSCAM-AS1 promotes breast cancer progression through inhibiting ferroptosis
Numerous studies have indicated that N6-methyladenosine (m6A) and lncRNAs play pivotal roles in human cancer. However, the underlying functions and mechanisms of m6A-lncRNA in the physiological processes of breas...
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Article
No prognostic impact of staging bone scan in patients with stage IA non-small cell lung cancer
To investigate the survival benefit of preoperative bone scan in asymptomatic patients with early-stage non-small cell lung cancer (NSCLC).
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Article
Prenatal Antidepressant Exposures and Autism Spectrum Disorder or Traits: A Retrospective, Multi-Cohort Study
Prenatal antidepressant exposure has been associated with increased risk for neurodevelopmental disorders in childhood, including autism spectrum disorder (ASD). The current study utilized multi-cohort data fr...
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Article
Impact of the COVID-19 pandemic on children’s sleep habits: an ECHO study
Sleep in childhood is affected by behavioral, environmental, and parental factors. We propose that these factors were altered during the COVID-19 pandemic. This study investigates sleep habit changes during th...
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Article
Open AccessAnticancer effects of dihydromyricetin on the proliferation, migration, apoptosis and in vivo tumorigenicity of human hepatocellular carcinoma Hep3B cells
Hepatocellular carcinoma (HCC) represents a serious public health problem worldwide and has high morbidity and mortality. Dihydromyricetin (DHM) exhibits anticancer effect on a variety of malignancies, but its...
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Article
Open Accessα-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation
Tri-methylation on lysine 40 of α-tubulin (α-TubK40me3) is a recently identified post-translational modification involved in mitosis and cytokinesis. However, knowledge about α-TubK40me3 in microtubule functio...
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Shanxi Yicheng Chengdong Renhe Iron & Steel Co., Ltd. v. Luoyang Pengfei Refractory and Wear-resistant Material Co. Ltd. et al. (Dispute over Sales Contract): The Debt Assumption Agreement is Revoked by the Court and the Creditor Can Only Request the Fulfillment of Debt Repayment by the Debtor
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Article
Evaluating the Contribution of the Physical and Biochemical Effects of Root on Detachment for the Coarse-Textured Soil from the Three Gorges Reservoir, China
Plant roots have great effect on the process of soil detachment, but the contribution of the physical and biochemical effects of root on soil detachment have not been sufficiently evaluated. For the purpose to...
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Article
Open AccessMuscarinic M1 and M2 receptor subtypes play opposite roles in LPS-induced septic shock
To compare pharmacologic effects of pirenzepine and AF-DX116, a selective competitive antagonist for M1 and M2 subtype muscarinic cholinergic receptors (mAChRs), respectively, with atropine, a non-selective co...
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Article
Open AccessJS-K, a nitric oxide donor, induces autophagy as a complementary mechanism inhibiting ovarian cancer
Ovarian cancer (OC) is the second most frequent gynecological cancer and is associated with a poor prognosis because OC progression is often asymptoma-tic and is detected at a late stage. There remains an urge...
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Article
Open AccessModelling soil detachment by overland flow for the soil in the Tibet Plateau of China
The overland flow erosion is common and became more serious because of the climate warming inducing more runoff in the Tibet Plateau. The purposes of this study were to evaluate the effects of flow rate, slope...
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Article
Open AccessTherapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma
Glioblastoma (GBM) is an aggressive primary human brain tumour that has resisted effective therapy for decades. Although glucose and glutamine are the major fuels that drive GBM growth and invasion, few studie...
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Article
miR-363-3p is activated by MYB and regulates osteoporosis pathogenesis via PTEN/PI3K/AKT signaling pathway
Osteoporosis results from the imbalance between osteogenesis and bone resorption mediated by osteoblasts and osteoclasts. During the disease process of osteoporosis, the alteration of gene expression occurs, w...
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Article
Open AccessmiR-589 promotes gastric cancer aggressiveness by a LIFR-PI3K/AKT-c-Jun regulatory feedback loop
As novel biomarkers for various cancers, microRNAs negatively regulate genes expression via promoting mRNA degradation and suppressing mRNA translation. miR-589 has been reported to be deregulated in several h...
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Article
Open AccessLASP1 promotes nasopharyngeal carcinoma progression through negatively regulation of the tumor suppressor PTEN
LIM and SH3 protein 1 (LASP1) enhances tumor growth and metastasis in various cancers, but its role in nasopharyngeal carcinoma (NPC) remains unclear. Herein, we investigated the role of LASP1 in NPC and explo...
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Article
Open AccessLoss of the 14-3-3σ is essential for LASP1-mediated colorectal cancer progression via activating PI3K/AKT signaling pathway
LIM and SH3 protein 1 (LASP1) can promote colorectal cancer (CRC) progression and metastasis, but the direct evidence that elucidates the molecular mechanism remains unclear. Here, our proteomic data showed th...
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Article
Mir-152 inhibits cell proliferation and colony formation of CD133+ liver cancer stem cells by targeting KIT
miR152 is involved in diverse biological functions and development of disease. This study investigates the role of mir-152 in cell proliferation and colony formation of liver cancer stem cells. We show that ex...
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Article
Open AccessDihydromyricetin promotes hepatocellular carcinoma regression via a p53 activation-dependent mechanism
The development of antitumor chemotherapy drugs remains a key goal for oncologists and natural products provide a vast resource for anti-cancer drug discovery. In the current study, we found that the flavonoid...
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Article
Physical simulation of fluid flow and production performance in extra-low permeability porous media
For extra-low permeability reservoirs, with a permeability of about 0.3×10−3 µm2, fluid flow and production performance in cores were studied. A long core holder with a multi-location piezometric measurement was ...
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Advanced Methods for Assessing the Stability and Control of Alternans
It is now widely accepted that rotating action potential waves propagating within the heart cause several types of abnormal rapid cardiac rhythm patterns. Many of these rotating waves are sustained purely thro...
