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Article
Open AccessEndosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection
Human C-type lectin member 18A (CLEC18A) is ubiquitously expressed in human, and highest expression levels are found in human myeloid cells and liver. In contrast, mouse CLEC18A (mCLEC18A) is only expressed in...
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Article
Open AccessAntibody blockade of Dectin-2 suppresses house dust mite-induced Th2 cytokine production in dendritic cell- and monocyte-depleted peripheral blood mononuclear cell co-cultures from asthma patients
Dectin-2, which is a C-type lectin, interacts with the house dust mite (HDM) Dermatophagoides pteronyssinus allergen. This study aimed to investigate whether Dectin-2 blockade by antagonistic monoclonal antibodie...
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Article
DcR3 suppresses influenza virus-induced macrophage activation and attenuates pulmonary inflammation and lethality
Influenza A virus (IAV) infects macrophages and stimulates innate immunity receptors and sensors to produce proinflammatory cytokines and chemokines, which are responsible for IAV-induced pulmonary inflammatio...
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Chapter and Conference Paper
Targeting C-Type Lectin for the Treatment of Flavivirus Infections
The genus Flavivirus contains approximately 70 viruses, and the major flaviviruses that cause human diseases are yellow fever virus (YFV), dengue virus (DV), West Nile virus (WNV), Japanese encephalitis virus (JE...
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Article
CLEC5A is critical for dengue-virus-induced lethal disease
Dengue haemorrhagic fever is transmitted by the bite of a mosquito infected with dengue virus. It infects more that 50 million people a year and causes some 20,000 deaths, but at present there are no vaccines ...
