4 Result(s)
within
Min-Sup Song
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessPTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a major dose-dependent tumor suppressor. The cellular mechanisms that control PTEN levels therefore offer potential routes...
-
Article
Open AccessLong-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting
Skeletal muscle wasting is prevalent in many chronic diseases, necessitating inquiries into molecular regulation of muscle mass. Nuclear receptor co-activator peroxisome proliferator-activated receptor co-acti...
-
Article
Open AccessExercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice
Dissecting exercise-mimicking pathways that can replicate the benefits of exercise in obesity and diabetes may lead to promising treatments for metabolic disorders. Muscle estrogen-related receptor gamma (ERRγ...
-
Article
The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
The exclusion of the tumour suppressor PTEN from the cell nucleus has been linked with tumour progression; the mechanisms behind its aberrant localization are obscure, although ubiquitinylation of specific lys...
