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    Article

    Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits

    Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms...

    Avik Choudhuri, Eirini Trompouki, Brian J. Abraham, Leandro M. Colli in Nature Genetics (2020)

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    Open Access

    Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation

    Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular ...

    David Adlam, Takiy-Eddine Berrandou, Adrien Georges in Nature Genetics (2023)

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    Article

    Sex-specific genetic architecture of blood pressure

    The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using t...

    Min-Lee Yang, Chang Xu, Trisha Gupte, Thomas J. Hoffmann in Nature Medicine (2024)