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Article
Sex-specific genetic architecture of blood pressure
The genetic and genomic basis of sex differences in blood pressure (BP) traits remain unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide association studies of BP traits using t...
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Article
Open AccessGenome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation
Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular ...
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Article
Open AccessAuthor Correction: Genetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
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Article
Open AccessGenetic investigation of fibromuscular dysplasia identifies risk loci and shared genetics with common cardiovascular diseases
Fibromuscular dysplasia (FMD) is an arteriopathy associated with hypertension, stroke and myocardial infarction, affecting mostly women. We report results from the first genome-wide association meta-analysis o...
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Article
Common variants in signaling transcription-factor-binding sites drive phenotypic variability in red blood cell traits
Genome-wide association studies identify genomic variants associated with human traits and diseases. Most trait-associated variants are located within cell-type-specific enhancers, but the molecular mechanisms...
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Article
Open AccessChromosome 1q21.2 and additional loci influence risk of spontaneous coronary artery dissection and myocardial infarction
Spontaneous coronary artery dissection (SCAD) is a non-atherosclerotic cause of myocardial infarction (MI), typically in young women. We undertook a genome-wide association study of SCAD (Ncases = 270/Ncontrols =...
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Article
Open AccessExome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese
Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genoty** 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify...
