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Article
RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer
Disabled tumor suppressor genes and hyperactive oncogenes greatly contribute to cell fates during cancer development because of their genetic alterations such as somatic mutations. However, little is known abo...
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Article
Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer
Hypoxia, or the deficiency of oxygen, in solid tumors is majorly responsible for the progression of cancer and remains unaffected by chemotherapy, but still requires definitive definition of the hypoxia signal...
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Article
RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer
RUNX3 is frequently inactivated by DNA hypermethylation in numerous cancers. Here, we show that RUNX3 has an important role in modulating apoptosis in immediate response to tumor necrosis factor-related apopto...