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Article
The Minnesota Green Tea Trial (MGTT), a randomized controlled trial of the efficacy of green tea extract on biomarkers of breast cancer risk: study rationale, design, methods, and participant characteristics
The Minnesota Green Tea Trial (MGTT) was a randomized, placebo-controlled, double-blinded trial investigating the effect of daily green tea extract consumption for 12 months on biomarkers of breast cancer risk.
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Article
Open AccessGenetic polymorphisms of epidermal growth factor in relation to risk of hepatocellular carcinoma: two case-control studies
Earlier, we reported a highly statistically significant association between T-helper 1 (Th1) and Th2 cytokine genotypes and hepatocellular carcinoma (HCC) risk among natives of southern Guangxi, China, a hyper...
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Article
Erratum to: Soy intake and risk of type 2 diabetes in Chinese Singaporeans
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Article
Soy intake and risk of type 2 diabetes mellitus in Chinese Singaporeans
To examine the association between soy products and their components, isoflavones and protein, and incident type 2 diabetes in a population with varied soy intake and high rates of diabetes.
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Article
Green and black tea intake in relation to prostate cancer risk among Singapore Chinese
Tea is one of the most commonly consumed beverages worldwide. To date, observational data from prospective cohort studies investigating the relationship between green and black tea intake and prostate cancer r...
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Article
Histological Versus Clinical Cirrhosis in Chronic Hepatitis C: Does Race/Ethnicity Really Matter?
Liver fibrosis progression in hepatitis C virus (HCV) infection has been in part associated with race/ethnicity. Little is known of the frequency of clinical cirrhosis in Asian patients in the US.
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Article
Combined effects of MDM2 SNP309 and TP53 R72P polymorphisms, and soy isoflavones on breast cancer risk among Chinese women in Singapore
The MDM2 oncoprotein regulates the p53 pathway and, while functional polymorphisms of the MDM2 and p53 genes have been investigated for association with breast cancer risk, results are largely null or non-conc...
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Article
Coffee consumption and reduced risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study
Coffee consumption has been associated with reduced markers of hepatic cell damage, reduced risk of chronic liver disease, and cirrhosis across a variety of populations. Data on the association between coffee ...
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Article
The tyranny of statistics in medicine: a critique of unthinking adherence to an arbitrary p value
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Article
Cigarette smoking and risk of prostate cancer among Singapore Chinese
Prospective epidemiologic studies conducted in Western populations support an association between current smoking and aggressive subtypes of prostate cancer. In Singapore, where prostate-specific antigen is no...
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Article
Sex differential in methylation patterns of selected genes in Singapore Chinese
To date there have been few reports of a gender difference in methylation levels of genes. When examining the methylation levels of four autosomal genes (ESR1, MTHFR, CALCA and MGMT) in the white blood cells of a...
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Article
Thymidylate synthase: a novel genetic determinant of plasma homocysteine and folate levels
The thymidylate synthase gene (TYMS or TS) encodes a tightly regulated enzyme that catalyzes the conversion of deoxyuridylate to thymidylate, and contains a tandem repeat polymorphism that affects expression of ...
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Article
Hypomethylation and hypermethylation of DNA in Wilms tumors
We quantitatively analysed hypermethylation at CpG islands in the 5′ ends of 12 genes and one non-CpG island 5′ region (MTHFR) in 31 Wilms tumors. We also determined their global genomic 5-methylcytosine content....
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Article
Lipid peroxidation: a novel and unifying concept of the etiology of renal cell carcinoma (United States)
Multiple studies have noted that obese individuals are at a high risk of renal cell cancer. Similarly, numerous case–control and cohort studies have consistently reported that individuals with a history of hyp...
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Article
Evidence of an X-linked or recessive genetic component to prostate cancer risk
We used data from a population-based cohort study of blacks, Hispanics, Japanese and whites to examine the frequency of prevalent prostate and breast cancer by family history status of first-degree relatives (...
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Article
Dietary β-carotene, cigarette smoking, and lung cancer in men
A cohort of 5,080 men living in a retirement community in California (United States) and initially free from lung cancer were followed from June 1981 to December 1989. At recruitment, each study participant co...
