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Article
DNA synthesis provides the driving force to accelerate DNA unwinding by a helicase
Helicases are molecular motors that use the energy of nucleoside 5′-triphosphate (NTP) hydrolysis to translocate along a nucleic acid strand and catalyse reactions such as DNA unwinding. The ring-shaped helicase1
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Article
A Brownian motor mechanism of translocation and strand separation by hepatitis C virus helicase
Helicases translocate along their nucleic acid substrates using the energy of ATP hydrolysis and by changing conformations of their nucleic acid–binding sites. Our goal is to characterize the conformational ch...
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Protocol
Model-Based Global Analysis of Heterogeneous Experimental Data Using gfit
Regression analysis is indispensible for quantitative understanding of biological systems and for develo** accurate computational models. By applying regression analysis, one can validate models and quantify...
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Protocol
Experimental and Computational Analysis of DNA Unwinding and Polymerization Kinetics
DNA unwinding and polymerization are complex processes involving many intermediate species in the reactions. Our understanding of these processes is limited because the rates of the reactions or the existence ...
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Article
Open Accessowlcpp: a C++ library for working with OWL ontologies
The increasing use of ontologies highlights the need for a library for working with ontologies that is efficient, accessible from various programming languages, and compatible with common computational platforms.
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Article
Open AccessVDJML: a file format with tools for capturing the results of inferring immune receptor rearrangements
The genes that produce antibodies and the immune receptors expressed on lymphocytes are not germline encoded; rather, they are somatically generated in each develo** lymphocyte by a process called V(D)J reco...
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Article
Open AccessVDJPipe: a pipelined tool for pre-processing immune repertoire sequencing data
Pre-processing of high-throughput sequencing data for immune repertoire profiling is essential to insure high quality input for downstream analysis. VDJPipe is a flexible, high-performance tool that can perfor...
