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    Model-Based Global Analysis of Heterogeneous Experimental Data Using gfit

    Regression analysis is indispensible for quantitative understanding of biological systems and for develo** accurate computational models. By applying regression analysis, one can validate models and quantify...

    Mikhail K. Levin, Manju M. Hingorani, Raquell M. Holmes, Smita S. Patel… in Systems Biology (2009)

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    TIRF(ing) reveals Msh2-Msh6 surfing on DNA

    Faced with the thermodynamic and kinetic challenge of finding a few specific sites on DNA among millions of nonspecific sites, within a limited amount of time, what's a protein to do? Single-molecule studies s...

    Manju M Hingorani in Nature Structural & Molecular Biology (2007)

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    A tale of toroids in DNA metabolism

    A strikingly large number of the proteins involved in DNA metabolism adopt a toroidal ? or ring-shaped ? quaternary structure, even though they have completely unrelated functions. Given that these proteins al...

    Manju M. Hingorani, Mike O'Donnell in Nature Reviews Molecular Cell Biology (2000)

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    Article

    DNA is bound within the central hole to one or two of the six subunits of the T7 DNA helicase

    Electron microscopic image analysis and protein–DNA crosslinking show that DNA binds asymmetrically to the hexameric bacteriophage T7 gp4b helicase, and binds to only one or two subunits

    **ong Yu, Manju M. Hingorani, Smita S. Patel… in Nature Structural Biology (1996)