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Article
Open AccessAnalysis of acid–base disorders in an ICU cohort using a computer script
Acid–base status is important for understanding pathophysiology, making a diagnosis, planning effective treatment and monitoring progress of critically ill patients. Manual calculations are cumbersome, easily ...
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Article
Open AccessMorbidity and mortality in critically ill patients with invasive group A streptococcus infection: an observational study
Group A streptococci (GAS) are known to cause serious invasive infections, but little is known about outcomes when patients with these infections are admitted to intensive care. We wanted to describe criticall...
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Article
Open AccessStreptococcal M1 protein induces hyporesponsiveness and cytokine release from human arteries in a fibrinogen-dependent manner: a translational study
Streptococcus pyogenes is a Gram positive bacterial species commonly involved in sepsis. Invasive strains express virulence factors such as the M1 protein. M1 protein forms complexes with fibrinogen leading to a ...
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Article
The human antimicrobial peptide LL-37 induces endothelium-dependent vascular smooth muscle relaxation mediated via the lipoxin A4 receptor
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Article
Open AccessHuman antimicrobial peptide LL-37 is present in atherosclerotic plaques and induces death of vascular smooth muscle cells: a laboratory study
Death of smooth muscle cells in the atherosclerotic plaques makes the plaques more prone to rupture, which can initiate an acute ischemic event. The development of atherosclerosis includes the migration of imm...