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Article
Calculation study on complex formation of catechins with β-cyclodextrin using density function theory
The inclusion of catechins with cyclodextrin (CD) is performed for the purpose of improving the water solubility and reducing the bitterness of catechins. In this study, the effect of catechins’ conformation o...
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Article
Difference in formation mechanism of inclusion complex between configuration isomers of gallate-type catechin and β-cyclodextrin
The formation mechanism of inclusion complex between (-)-epigallocatechin gallate (EGCg), which is the main catechin in tea leaves, or (-)-gallocatechin gallate (GCg), which is an isomer of EGCg, and β-cyclode...
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Article
Effect of solution pH on complex formation between epi-type catechin and β-cyclodextrin
The effect of solution pH on the formation of an inclusion complex between (−)-epigallocatechin gallate (EGCg: pKa = 7.5) and β-cyclodextrin (β-CD) was investigated by isothermal titration calorimetry and 1H-NMR ...
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Article
Improving water solubility of nateglinide by complexation of β-cyclodextrin
Inclusion complex of anionic nateglinide (NTG) with β-cyclodextrin (βCD) has been prepared to improve the water solubility of NTG. The mechanism of the complexation was elucidated using isothermal titration ca...
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Article
Drug–tea polyphenol interaction
Propericiazine (PCZ) is an antipsychotic agent used for the treatment and the prevention of relapse of schizophrenia. We found that when an oral solution containing PCZ was mixed with a green tea drink, the re...
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Article
Determination of Digoxin Clearance in Japanese Elderly Patients for Optimization of Drug Therapy
Background: Optimal use of digoxin in the elderly population requires information about the drug’s pharmacokinetics and the influence of various factors on the drug’s disposition. However, becaus...
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Article
Population Pharmacokinetics of Haloperidol Using Routine Clinical Pharmacokinetic Data in Japanese Patients
To clarify the observed variability of haloperidol disposition in patients with psychiatric disorders.
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Article
Population Pharmacokinetics of Digoxin in Japanese Patients
To clarify the observed variability of digoxin disposition by performing a population pharmacokinetic analysis in a Japanese population.
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Article
Population-based investigation of relative clearance of digoxin in Japanese neonates and infants by multiple-trough screen analysis
Objective: The steady-state concentrations of digoxin at trough levels were studied to establish the role of patient characteristics in estimating doses for digoxin using routine therapeutic dru...