4 Result(s)

Article

Live imaging of apoptotic signaling flow using tunable combinatorial FRET-based bioprobes for cell population analysis of caspase cascades

Understanding cellular signaling flow is required to comprehend living organisms. Various live cell imaging tools have been developed but challenges remain due to complex cross-talk between pathways and respon...

Miho Suzuki, Yutaka Shindo, Ryu Yamanaka, Kotaro Oka in Scientific Reports (2022)

Article

Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice

Aging is considered to be accelerated by insulin signaling in lower organisms, but it remained unclear whether this could hold true for mammals. Here we show that mice with skeletal muscle-specific double knoc...

Takayoshi Sasako, Toshihiro Umehara, Kotaro Soeda, Kazuma Kaneko… in Nature Communications (2022)

Article

Both T cell priming in lymph node and CXCR3-dependent migration are the key events for predicting the response of atezolizumab

Anti-PD-L1 antibodies benefit many cancer patients, even those with “non-inflamed tumor”. Determining which patients will benefit remains an important clinical goal. In a non-inflamed tumor mouse model, we fou...

Toshiki Iwai, Masamichi Sugimoto, Namrata S. Patil, Daniel Bower… in Scientific Reports (2021)

Article

Transposable element in fish

Akihiko Koga, Miho Suzuki, Hidehito Inagaki, Yoshitaka Bessho, Hiroshi Hori in Nature (1996)