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Article
A High Proliferation Rate is Critical for Reproducible and Standardized Embryoid Body Formation from Laminin-521-Based Human Pluripotent Stem Cell Cultures
When aiming for homogenous embryoid body (EB) differentiation, the use of equal-sized EBs is required to avoid a size-induced differentiation bias. In this study we developed an efficient and standardized EB f...
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Article
Role of BMP Signaling in Pancreatic Progenitor Differentiation from Human Embryonic Stem Cells
Transplantation of pancreatic progenitors derived from human embryonic stem cells (hESCs) is a promising way to treat diabetes. Strategies to obtain the required cell mass would rely on the up scaling of curre...
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Article
Human embryonic stem cells commonly display large mitochondrial DNA deletions
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Protocol
Establishment of hESC Lines from the Inner Cell Mass of Blastocyst-Stage Embryos and Single Blastomeres of 4-Cell Stage Embryos
More than 600 human embryonic stem cell (hESC) lines have been reported today at the human European Embryonic Stem Cell Registry (http://www.hescreg.eu/). Despite these ...
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Article
Recurrent chromosomal abnormalities in human embryonic stem cells
During long-term culture, human embryonic stem (hES) cells may acquire chromosomal abnormalities that compromise their potential clinical utility. A study of 17 hES cell lines reveals various genomic changes, ...