-
Article
Identification of Galectin-7 as a crucial metastatic enhancer of squamous cell carcinoma associated with immunosuppression
Metastasis predicts poor prognosis in cancer patients. It has been recognized that specific tumor microenvironment defines cancer cell metastasis, whereas the underlying mechanisms remain elusive. Here we show...
-
Article
Open AccessACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury
Angiotensin-converting enzyme 2 (ACE2) is a receptor for cell entry of SARS-CoV-2, and recombinant soluble ACE2 protein inhibits SARS-CoV-2 infection as a decoy. ACE2 is a carboxypeptidase that degrades angiot...
-
Article
Open AccessB38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction
Angiotensin-converting enzyme 2 (ACE2) is critically involved in cardiovascular physiology and pathology, and is currently clinically evaluated to treat acute lung failure. Here we show that the B38-CAP, a car...
-
Article
Pulmonary phagocyte-derived NPY controls the pathology of severe influenza virus infection
Crosstalk between the autonomic nervous system and the immune system by means of the sympathetic and parasympathetic pathways is a critical process in host defence. Activation of the sympathetic nervous system...
