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Open AccessReply to ‘Fetal side’ of the placenta: Anatomical mis-annotation of carbon particle ‘transfer’ across the human placenta
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Open AccessEstablishing reference values for macro- and microvascular measurements in 4-to-5 year-old children of the ENVIRONAGE prospective birth cohort
Cardiovascular risk factors are usually better tolerated, and can therefore be perceived as less harmful, at a young age. However, over time the effects of these adverse factors may persist or accumulate and l...
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Open AccessBreastfeeding predicts blood mitochondrial DNA content in adolescents
Nutrition during early childhood is linked to metabolic programming. We hypothesized that breastfeeding has long-term consequences on the energy metabolism exemplified by mitochondrial DNA (mtDNA). As part of ...
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Open AccessAmbient black carbon particles reach the fetal side of human placenta
Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-der...
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Open AccessMeta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birt...
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Open AccessChildren’s screen time alters the expression of saliva extracellular miR-222 and miR-146a
An imbalance between energy uptake and energy expenditure is the most important reason for increasing trends in obesity starting from early in life. Extracellular miRNAs are expressed in all bodily fluids and ...
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Open AccessRetinal microcirculation and leukocyte telomere length in the general population
Retinal arteriolar narrowing increases with age and predict adverse cardiovascular outcomes. Telomere length keeps track of the division of somatic cells and is a biomarker of biological age. We investigated t...
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Open AccessStem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds
One of the major challenges in the development of alternative carcinogenicity assays is the prediction of non-genotoxic carcinogens. The variety of non-genotoxic cancer pathways complicates the search for reli...