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Article
Open AccessGlycolytic competence in gastric adenocarcinomas negatively impacts survival outcomes of patients treated with salvage paclitaxel-ramucirumab
For energy production, cancer cells maintain a high rate of glycolysis instead of oxidative phosphorylation converting glucose into lactic acid. This metabolic shift is useful to survive in unfavorable microen...
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Chapter and Conference Paper
An Application and Integration of Machine Learning Approach on a Real IoT Agricultural Scenario
The Internet of Things (IoT) paradigm applied to the agriculture field provides a huge amount of data allowing the employment of Artificial Intelligence for multiple tasks. In this work, solar radiation predic...
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Article
Personalized 177Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: initial results from the P-PRRT trial
Peptide receptor radionuclide therapy (PRRT) is mostly administered using a fixed injected activity (IA) per cycle. This empiric regime results in highly variable absorbed doses to the critical organs and unde...
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Article
Open AccessAccuracy and reproducibility of simplified QSPECT dosimetry for personalized 177Lu-octreotate PRRT
Routine dosimetry is essential for personalized 177Lu-octreotate peptide receptor radionuclide therapy (PRRT) of neuroendocrine tumors (NETs), but practical and robust dosimetry methods are needed for wide clinic...
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Article
The antiproliferative effect of pasireotide LAR alone and in combination with everolimus in patients with medullary thyroid cancer: a single-center, open-label, phase II, proof-of-concept study
Medullary thyroid cancer (MTC) is a neuroendocrine tumour of the thyroid C cells. Pasireotide, a multi-receptor targeted somatostatin analogue, and everolimus, an inhibitor of mTOR, showed antitumour propertie...
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Article
A germline missense mutation in exon 3 of the MSH2 gene in a Lynch syndrome family: correlation with phenotype and localization assay
Lynch syndrome is caused by germline mutations in any of the MisMatch Repair (MMR) genes. About 37% of MSH2 variants are missense variants causing single amino-acid substitutions. Whether missense variants affect...
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Article
Personalized 177Lu-octreotate peptide receptor radionuclide therapy of neuroendocrine tumours: a simulation study
Peptide receptor radionuclide therapy (PRRT) with 177Lu-octreotate is commonly administered at empiric, fixed amounts of injected radioactivity (IA). This results in highly variable absorbed doses to critical org...
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Article
Open AccessOff-target effects and clinical outcome in metastatic colorectal cancer patients receiving regorafenib: The TRIBUTE analysis
Regorafenib is an orally administered multikinase inhibitor indicated for the treatment of heavily pretreated metastatic colorectal cancer patients with good performance status, albeit less than 50% treated pa...
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Article
Mismatch repair deficiency may affect clinical outcome through immune response activation in metastatic gastric cancer patients receiving first-line chemotherapy
The microsatellite-instable gastric cancer subtype, because of its supposed high antigenic potential, is a promising candidate for immunotherapy. We analyzed if the presence of a defective mismatch repair (MMR...
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Article
Open AccessAngiogenesis genoty** and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients
Regorafenib monotherapy is a potential option for metastatic colorectal cancer patients. However, the lack of predictive factors and the severe toxicities related to treatment have made its use in clinical pra...
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Article
Open AccessThe correlation between LDH serum levels and clinical outcome in advanced biliary tract cancer patients treated with first line chemotherapy
LDH may represent an indirect marker of neo-angiogenesis and worse prognosis in many tumour types. We assessed the correlation between LDH and clinical outcome for biliary tract cancer (BTC) patients treated w...
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Article
Open AccessThree drugs vs two drugs first-line chemotherapy regimen in advanced gastric cancer patients: a retrospective analysis
The definition of the standard chemotherapy regimen for advanced gastric cancer is still a matter of debate. Aim of our analysis was to retrospectively assess whether an intensive, three-drugs, front line appr...
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Article
Second-line sunitinib as a feasible approach for iodine-refractory differentiated thyroid cancer after the failure of first-line sorafenib
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Article
Open AccessProspective study of a molecular selection profile for RAS wild type colorectal cancer patients receiving irinotecan-cetuximab
The aim of our study was to evaluate whether a panel of biomarkers, prospectively analysed might be able to predict patients’ clinical outcome more accurately than RAS status alone.
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Article
Potential role of cinacalcet hydrochloride in sporadic primary hyperparathyroidism without surgery indication
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Article
Transarterial embolization (TAE) is equally effective and slightly safer than transarterial chemoembolization (TACE) to manage liver metastases in neuroendocrine tumors
Liver metastases from neuroendocrine tumor (NET) can be treated by transarterial embolization (TAE) or transarterial chemoembolization (TACE). The goal of TAE and TACE is to reduce blood flow to the tumor resu...
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Article
Combined biological therapy with lanreotide autogel and cabergoline in the treatment of MEN-1-related insulinomas
Multiple endocrine neoplasia type 1 (MEN1) is a hereditary syndrome associated with the development of many endocrine tumors, involving mainly pituitary, parathyroids, pancreas, although a proliferative state...
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Article
Open AccessHepatic arterial embolization in patients with neuroendocrine tumors
Liver metastases occur in 46-93% of patients with neuroendocrine neoplasms (NENs). Presence and extension of liver metastases are considered important prognostic factors, as they may significantly impair the p...
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Article
Open AccessThe role of LDH serum levels in predicting global outcome in HCC patients treated with sorafenib: implications for clinical management
In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of tumour hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is an important predic...
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Article
La gestione multidisciplinare della malattia di Anderson-Fabry: il ruolo dell’endocrinologo
La malattia di Anderson-Fabry è un disordine genetico X-linked caratterizzato dal deficit dell’enzima lisosomiale α-galattosidasi-A con conseguente accumulo sistemico di substrati lipidic...
