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Open AccessAldolase positively regulates of the canonical Wnt signaling pathway
The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The ...
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Article
Erratum to: A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents
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A flow cytometry-based reporter assay identifies macrolide antibiotics as nonsense mutation read-through agents
A large number of human diseases are caused by nonsense mutations. These mutations result in premature protein termination and the expression of truncated, usually nonfunctional products. A promising therapeut...
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Article
Open AccessThe effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells
Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inh...
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Open AccessHigh-Temperature Requirement A1 (Htra1) - A Novel Regulator of Canonical Wnt Signaling
Different cancer types as well as many other diseases are caused by aberrant activation of the canonical Wnt signal transduction pathway, and it is especially implicated in the development and progression of c...
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Article
Serum starvation enhances nonsense mutation readthrough
Of all genetic mutations causing human disease, premature termination codons (PTCs) that result from splicing defaults, insertions, deletions, and point mutations comprise around 30%. From these mutations, aro...
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Article
Open AccessA CRISPR knockout screen reveals new regulators of canonical Wnt signaling
The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including canc...
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Article
Open AccessWnt signaling regulates chemokine production and cell migration of circulating human monocytes
The β-catenin dependent canonical Wnt signaling pathway plays a crucial role in maintaining normal homeostasis. However, when dysregulated, Wnt signaling is closely associated with various pathological conditi...
