3 Result(s)
within
Michal Caspi
Oncology
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Article
Open AccessAldolase positively regulates of the canonical Wnt signaling pathway
The Wnt signaling pathway is an evolutionary conserved system, having pivotal roles during animal development. When over-activated, this signaling pathway is involved in cancer initiation and progression. The ...
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Article
Open AccessThe effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells
Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inh...
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Article
Open AccessA CRISPR knockout screen reveals new regulators of canonical Wnt signaling
The Wnt signaling pathways play fundamental roles during both development and adult homeostasis. Aberrant activation of the canonical Wnt signal transduction pathway is involved in many diseases including canc...
