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  1. No Access

    Article

    Comparative benefits of social housing and buprenorphine on wheel running depressed by morphine withdrawal in rats

    Social support and opioid replacement therapy are commonly used to treat opioid withdrawal.

    Jonah D. Stickney, Michael M. Morgan in Psychopharmacology (2021)

  2. Article

    Contribution of Adenylyl Cyclase Modulation of Pre- and Postsynaptic GABA Neurotransmission to Morphine Antinociception and Tolerance

    Opioid inhibition of presynaptic GABA release in the ventrolateral periaqueductal gray (vlPAG) activates the descending antinociception pathway. Tolerance to repeated opioid administration is associated with u...

    Erin N Bobeck, QiLiang Chen, Michael M Morgan, Susan L Ingram in Neuropsychopharmacology (2014)

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  3. No Access

    Article

    Contribution of dopamine receptors to periaqueductal gray-mediated antinociception

    Morphine relieves pain, in part, by acting on neurons within the periaqueductal gray (PAG). Given that the PAG contains a subpopulation of dopamine neurons, dopamine may contribute to the antinociceptive effec...

    Paul J. Meyer, Michael M. Morgan, Laura B. Kozell, Susan L. Ingram in Psychopharmacology (2009)

  4. Article

    Tolerance to Repeated Morphine Administration Is Associated with Increased Potency of Opioid Agonists

    Tolerance to the pain-relieving effects of opiates limits their clinical use. Although morphine tolerance is associated with desensitization of μ-opioid receptors, the underlying cellular mechanisms are not under...

    Susan L Ingram, Tara A Macey, Erin N Fossum, Michael M Morgan in Neuropsychopharmacology (2008)

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  5. Article

    Behavioral and Electrophysiological Evidence for Opioid Tolerance in Adolescent Rats

    Morphine and other opiates are successful treatments for pain, but their usefulness is limited by the development of tolerance. Given that recent studies have observed differential sensitivity to drugs of abus...

    Susan L Ingram, Erin N Fossum, Michael M Morgan in Neuropsychopharmacology (2007)

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  6. No Access

    Article

    Different effects of chronic nicotine treatment regimens on body weight and tolerance in the rat

    The effect of different chronic nicotine administration regimens on body weight and the development of tolerance was examined in female rats. Groups of animals were either treated with nicotine via a subcutane...

    Michael M. Morgan, Gaylord Ellison in Psychopharmacology (1987)