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Different effects of chronic nicotine treatment regimens on body weight and tolerance in the rat

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  1. Article

    Behavioral and Electrophysiological Evidence for Opioid Tolerance in Adolescent Rats

    Morphine and other opiates are successful treatments for pain, but their usefulness is limited by the development of tolerance. Given that recent studies have observed differential sensitivity to drugs of abus...

    Susan L Ingram, Erin N Fossum, Michael M Morgan in Neuropsychopharmacology (2007)

  2. Article

    Tolerance to Repeated Morphine Administration Is Associated with Increased Potency of Opioid Agonists

    Tolerance to the pain-relieving effects of opiates limits their clinical use. Although morphine tolerance is associated with desensitization of μ-opioid receptors, the underlying cellular mechanisms are not under...

    Susan L Ingram, Tara A Macey, Erin N Fossum, Michael M Morgan in Neuropsychopharmacology (2008)

  3. Article

    Contribution of Adenylyl Cyclase Modulation of Pre- and Postsynaptic GABA Neurotransmission to Morphine Antinociception and Tolerance

    Opioid inhibition of presynaptic GABA release in the ventrolateral periaqueductal gray (vlPAG) activates the descending antinociception pathway. Tolerance to repeated opioid administration is associated with u...

    Erin N Bobeck, QiLiang Chen, Michael M Morgan, Susan L Ingram in Neuropsychopharmacology (2014)

  4. Article

    Open Access

    Depression of home cage wheel running: a reliable and clinically relevant method to assess migraine pain in rats

    The development of new anti-migraine treatments is limited by the difficulty inassessing migraine pain in laboratory animals. Depression of activity is one of the few diagnostic criteria formigraine that can b...

    Ram Kandasamy, Andrea T. Lee, Michael M. Morgan in The Journal of Headache and Pain (2017)