5 Result(s)
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Article
Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin
Ewan Pearson, Kathleen Giacomini and the Metformin Genetics Consortium perform a genome-wide association study for glycemic response to the antidiabetic drug metformin. They find an intronic allele of the GLUT...
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Article
Open AccessA retrospective chart review of drug treatment patterns and clinical outcomes among patients with metastatic or recurrent soft tissue sarcoma refractory to one or more prior chemotherapy treatments
Limited clinical data on real-world practice patterns are available for patients with metastatic/relapsed soft tissue sarcomas (STS). The primary objective of this study was to evaluate treatment patterns in p...
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Article
Open AccessErratum to: Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics
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Article
Open AccessApplication of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics
The goal of this study was to perform candidate gene association with cytotoxicity of chemotherapeutics in cell line models through resequencing and discovery of rare and low frequency variants along with comm...
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Article
Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)
Hereditary multiple exostoses is an autosomal dominant disorder that is characterized by short stature and multiple, benign bone tumours. In a majority of families, the genetic defect (EXT1) is linked to the Lang...
