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METAPANC
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Open AccessVisualization of deglutition and gastroesophageal reflux using real-time MRI: a standardized approach to image acquisition and assessment
This study aims to develop a standardized algorithm for gastroesophageal image acquisition and diagnostic assessment using real-time MRI. Patients with GERD symptoms undergoing real-time MRI of the esophagus a...
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Open AccessSerum immune checkpoint profiling identifies soluble CD40 as a biomarker for pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) responds poorly to systemic treatment, including new immunotherapeutic approaches. Biomarkers are urgently needed for early disease detection, patient stratification for...
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Therapieempfehlung und Versorgung bei traumatischer Milzruptur
Die Milz ist bei stumpfen abdominellen Traumata das am häufigsten betroffene Organ. Zur initialen Diagnostik gehören die körperliche Untersuchung, die laborchemische Kontrolle sowie die Sonographie. Im Weitere...
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Hepatic arterial infusion with nanoliposomal irinotecan leads to significant regression of tumor size of colorectal liver metastases in a CC531 rat model
Long-term therapy for unresectable colorectal liver metastases remains challenging. Intraarterial treatments aim to avoid systemic adverse effects of chemotherapy. Nanoliposomal cytotoxic drugs manage to incre...
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Open AccessMolecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution
Colorectal cancer liver metastases (CRCLM) are associated with a poor prognosis, reflected by a five-year survival rate of 14%. Anti-angiogenic therapy through anti-VEGF antibody administration is one of the l...
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Open AccessIncidence and impact of new-onset postoperative arrhythmia after surgery of the lower gastrointestinal tract
Postoperative arrhythmias (PAs) are common events and have been widely investigated in cardiothoracic surgery. Within visceral surgery, a recent study revealed a significant occurrence of PA in esophageal rese...
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Living Reference Work Entry In depth
Rektumkarzinom: Radikale operative Therapie
Die Therapie des Rektumkarzinoms ist sehr komplex und häufig eingebunden in interdisziplinäre Behandlungskonzepte. Während ein T1-Karzinom ohne Risikofaktoren und ohne Hinweis auf Lymphknotenmetastasen lokal e...
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Open AccessOutcomes and risks in palliative pancreatic surgery: an analysis of the German StuDoQ|Pancreas registry
Non-resectability is common in patients with pancreatic ductal adenocarcinoma (PDAC) due to local invasion or distant metastases. Then, biliary or gastroenteric bypasses or both are often established despite a...
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Open AccessTreatment options of metastatic and nonmetastatic VIPoma: a review
VIPoma belongs to the group of neuroendocrine neoplasms. These tumours are located mostly in the pancreas and produce high levels of vasoactive intestinal peptide (VIP). In most cases, a metastatic state has a...
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Open AccessGene-expression profiles of pretreatment biopsies predict complete response of rectal cancer patients to preoperative chemoradiotherapy
Preoperative (neoadjuvant) chemoradiotherapy (CRT) and total mesorectal excision is the standard treatment for rectal cancer patients (UICC stage II/III). Up to one-third of patients treated with CRT achieve a...
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Open AccessNeedle tract seeding and abdominal recurrence following pre-treatment biopsy of gastrointestinal stromal tumors (GIST): results of a systematic review
Gastrointestinal stromal tumors (GIST) are rare abdominal tumors. Pretreatment biopsies may be used to diagnose a GIST and enable tailored treatment. Some experts are skeptical about biopsies because they fear...
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Open AccessAssessment of esophagogastric junction morphology by dynamic real-time MRI: comparison of imaging features to high-resolution manometry
To assess the esophagogastric junction (EGJ) on real-time MRI and compare imaging parameters to EGJ morphology on high-resolution manometry (HRM).
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Arbeitsgruppen zu kolorektalen Tumoren der AIO, der ACO und der ARO – „past, present, and future“
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International consensus recommendations on key outcome measures for organ preservation after (chemo)radiotherapy in patients with rectal cancer
Multimodal treatment strategies for patients with rectal cancer are increasingly including the possibility of organ preservation, through nonoperative management or local excision. Organ preservation strategie...
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Article
Open AccessRNF20 and RNF40 regulate vitamin D receptor-dependent signaling in inflammatory bowel disease
Despite the identification of several genetic factors linked to increased susceptibility to inflammatory bowel disease (IBD), underlying molecular mechanisms remain to be elucidated in detail. The ubiquitin li...
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Article
Einfluss der Molekularpathologie auf die onkologische Chirurgie des kolorektalen Karzinoms
Das kolorektale Karzinom (KRK) ist noch immer eine der häufigsten Krebserkrankungen und eines der auf molekularer Ebene am besten charakterisierten Malignome. Interdisziplinäre sowie multimodale Behandlungsstr...
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Open AccessChirurgische Therapie des Ösophaguskarzinoms – Qualitätsindikatoren für Diagnostik und Therapie
Im Rahmen der Qualitätsinitiative der Deutschen Gesellschaft für Allgemein- und Viszeralchirurgie (DGAV) wurde eine Übersichtsarbeit auf der Grundlage einer systematischen Literatursuche verfasst und Empfehlun...
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Chirurgische Resektion: offen, laparoskopisch, robotisch
Bei einem Großteil der Patienten mit Rektumkarzinom wird der Tumor minimal-invasiv reseziert, in der chirurgischen Therapie des Kolonkarzinoms überwiegt aber noch die offene Resektionstechnik.
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Klinische Komplettremission beim Rektumkarzinom: Wann ist weniger mehr?
Nach neoadjuvanter Radiochemotherapie (RCT) wird bei 10–20 % der Patienten mit lokal fortgeschrittenem Rektumkarzinom eine pathologische Komplettremission nachgewiesen.
