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Article
Open AccessE3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegeneration
Activated microglia have been implicated in the pathogenesis of age-related macular degeneration (AMD), diabetic retinopathy, and other neurodegenerative and neuroinflammatory disorders, but our understanding ...
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Chapter and Conference Paper
Feature Extraction of Point Rail of High-Speed Railway Turnout Through Oscillatory Behavior Based Signal Decomposition
Turnouts, due to their special structure, are prone to failure. A valuable way to monitor their health conditions is by analyzing wheel-rail force signals, as they are rich in information about the health cond...
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Article
Dynamic Multilayer Network for Systemic Risk and Bank Regulation Based on CDS
During the U.S. subprime mortgage crisis, credit default swaps (CDS) played a pivotal role and became an influential booster. However, most studies only study the systemic risk of CDS in the interbank market a...
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Article
Open AccessChronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils
Breast cancer can metastasize to various organs, including the lungs. The immune microenvironment of the organs to be metastasized plays a crucial role in the metastasis of breast cancer. Infection with pathog...
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Article
Open AccessForward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis
Microglia play a role in the pathogenesis of many retinal diseases. Fundus spots in mice often correlate with the accumulation of activated subretinal microglia. Here we use a semiquantitative fundus spot scor...
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Article
Enhancing Oxygen Reduction Reaction Catalytic Performance of Biomass-Derived Carbon Materials by Ultrasonication Treatment
Biomass-derived carbon materials have been widely studied as oxygen reduction reaction (ORR) catalysts in recent years, and most directly carbonized materials are still inferior to commercial 20% Pt/C in ORR p...
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Article
Open AccessAn Improved Time Domain Approach for Analysis of Floating Bridges Based on Dynamic Finite Element Method and State-Space Model
The floating bridge bears the dead weight and live load with buoyancy, and has wide application prospect in deep-water transportation infrastructure. The structural analysis of floating bridge is challenging d...
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Article
GNSS2TWS: an open-source MATLAB-based tool for inferring daily terrestrial water storage changes using GNSS vertical data
Technological advances in global navigation satellite system (GNSS) offer a novel environmental sensor to measure terrestrial water cycles and provide independent constraints on total terrestrial water storage...
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Article
Open AccessLoss of immunity-related GTPase GM4951 leads to nonalcoholic fatty liver disease without obesity
Obesity and diabetes are well known risk factors for nonalcoholic fatty liver disease (NAFLD), but the genetic factors contributing to the development of NAFLD remain poorly understood. Here we describe two se...
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Article
Open AccessGRB10 is a novel oncogene associated with cell proliferation and prognosis in glioma
Glioma is the most common malignant tumor of the central nervous system and is associated with a poor prognosis. This study aimed to explore the function of growth factor receptor-bound protein 10(GRB 10) in g...
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Article
Periplaneta americana extract ameliorates dextran sulfate sodium-induced ulcerative colitis via immunoregulatory and PI3K/AKT/NF-κB signaling pathways
Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with a low cure rate. Periplaneta americana is a traditional American Cockroach and reportedly has potential therapeutic roles for UC treatmen...
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Article
Open AccessMini-XT, a miniaturized tagmentation-based protocol for efficient sequencing of SARS-CoV-2
The COVID-19 pandemic has highlighted the importance of whole genome sequencing (WGS) of SARS-CoV-2 to inform public health policy. By enabling definition of lineages it facilitates tracking of the global spre...
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Article
Bayesian Water Quality Evaluation Model Based on Generalized Triangular Fuzzy Number and its Application
In view of the incompatibility of various indicators in water quality evaluation, as well as the uncertainty and fuzziness of water quality grade, this paper introduces the Bayesian theory and fuzzy number the...
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Article
An improved Taguchi multi-criteria decision-making method based on the hesitant fuzzy correlation coefficient and its application in quality evaluation
This article is aimed at exploring an improved Taguchi SNR technique to settle the problem of multi-criteria decision-making (MCDM) in a hesitant fuzzy situation. Firstly, a novel correlation coefficient is de...
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Article
Open AccessN4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization
Many immune responses depend upon activation of NF-κB, an important transcription factor in the elicitation of a cytokine response. Here we show that N4BP1 inhibits TLR-dependent activation of NF-κB by interac...
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Article
Open AccessMacrophage to myofibroblast transition contributes to subretinal fibrosis secondary to neovascular age-related macular degeneration
Macular fibrosis causes irreparable vision loss in neovascular age-related macular degeneration (nAMD) even with anti-vascular endothelial growth factor (VEGF) therapy. Inflammation is known to play an importa...
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Article
Comparison between non-visualized polyps and visualized polyps on optical coherence tomography angiography in polypoidal choroidal vasculopathy
To determine the underlying reasons for the non-visualization of polyps on en face optical coherence tomography angiography (OCTA) in patients with polypoidal choroidal vasculopathy (PCV).
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Article
Syndromic immune disorder caused by a viable hypomorphic allele of spliceosome component Snrnp40
We report a new immunodeficiency disorder in mice caused by a viable hypomorphic mutation of Snrnp40, an essential gene encoding a subunit of the U5 small nuclear ribonucleoprotein (snRNP) complex of the spliceos...
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Article
Isoquercetin Ameliorates Cerebral Impairment in Focal Ischemia Through Anti-Oxidative, Anti-Inflammatory, and Anti-Apoptotic Effects in Primary Culture of Rat Hippocampal Neurons and Hippocampal CA1 Region of Rats
Ischemic stroke is a major disability and cause of death worldwide due to its narrow therapeutic time window. Neuroprotective agent is a promising strategy to salvage acutely ischemic brain tissue and extend t...
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Article
Rapid growth of angle-confined large-domain graphene bicrystals
In the chemical vapor deposition growth of large-area graphene polycrystalline thin films, the coalescence of randomly oriented graphene domains results in a high density of uncertain grain boundaries (GBs). T...
