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  1. No Access

    Article

    A phase i study of ixazomib and erlotinib in patients with advanced solid tumors

    Background. Preclinical studies have shown that the combined inhibition of EGFR and NF-kB pathways to target the RalB/TBK1 pathway led to synergistic antitumor activity. Based on this rationale, we conducted a Ph...

    Shumei Kato, Jacob J. Adashek, Vivek Subbiah, Siqing Fu… in Investigational New Drugs (2022)

  2. Article

    Open Access

    The alkylphospholipid, perifosine, radiosensitizes prostate cancer cells both in vitro and in vivo

    Perifosine is a membrane-targeted alkylphospholipid developed to inhibit the PI3K/Akt pathway and has been suggested as a favorable candidate for combined use with radiotherapy. In this study, we investigated ...

    Yuanhong Gao, Hiromichi Ishiyama, Mianen Sun, Kathryn L Brinkman… in Radiation Oncology (2011)

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