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Article
Parallel pathways for serotonin biosynthesis and metabolism in C. elegans
The neurotransmitter serotonin plays a central role in animal behavior and physiology, and many of its functions are regulated via evolutionarily conserved biosynthesis and degradation pathways. Here we show t...
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Article
Publisher Correction: Parallel pathways for serotonin biosynthesis and metabolism in C. elegans
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Article
Open AccessObesity exacerbates colitis-associated cancer via IL-6-regulated macrophage polarisation and CCL-20/CCR-6-mediated lymphocyte recruitment
Colorectal cancer (CRC) is one of the most lethal cancers worldwide in which the vast majority of cases exhibit little genetic risk but are associated with a sedentary lifestyle and obesity. Although the mecha...
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Article
Open AccessSingle and Transient Ca2+ Peaks in Podocytes do not induce Changes in Glomerular Filtration and Perfusion
Chronic alterations in calcium (Ca2+) signalling in podocytes have been shown to cause proteinuria and progressive glomerular diseases. However, it is unclear whether short Ca2+ peaks influence glomerular biology...
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Article
Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
The role of IL-6 in obesity-associated inflammation remains controversial. Bruening and colleagues identify signaling by IL-6 as an important determinant for the alternative activation of macrophages during in...
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Article
Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b
The livers of obese mice and humans show increased levels of miR-802 resulting in impaired glucose tolerance and decreased insulin sensitivity through silencing of Hnf1b, revealing a novel pathway with potential ...
