-
Article
Open AccessThe role of targeting CDK4/6 in cancer immunotherapy
Cyclin-dependent kinase 4/6 (CDK4/6) acts as a crucial point of regulation in the G1-to-S transition in the cell division cycle, its aberrant activation was found in various human cancers, leading to abnormal ...
-
Article
Open AccessGenome-wide analysis of the switchgrass YABBY family and functional characterization of PvYABBY14 in response to ABA and GA stress in Arabidopsis
The small YABBY plant-specific transcription factor has a prominent role in regulating plant growth progress and responding to abiotic stress.
-
Article
Open AccessSOX on tumors, a comfort or a constraint?
The sex-determining region Y (SRY)-related high-mobility group (HMG) box (SOX) family, composed of 20 transcription factors, is a conserved family with a highly homologous HMG domain. Due to their crucial role...
-
Article
Open AccessTranscription factor BACH1 in cancer: roles, mechanisms, and prospects for targeted therapy
Transcription factor BTB domain and CNC homology 1 (BACH1) belongs to the Cap ‘n’ Collar and basic region Leucine Zipper (CNC-bZIP) family. BACH1 is widely expressed in mammalian tissues, where it regulates ep...
-
Article
Open AccessSecurity Energy Efficiency Analysis of CR-NOMA Enabled IoT Systems for Edge-cloud Environment
With the development of the Internet of Things (IoT), more and more devices are connected in edge-cloud environment, and spectrum scarcity has become a major bottleneck for the employment of IoT devices in the...
-
Article
Open AccessHGF-mediated elevation of ETV1 facilitates hepatocellular carcinoma metastasis through upregulating PTK2 and c-MET
Metastasis is a major determinant of death in patients with hepatocellular carcinoma (HCC). Dissecting key molecular mediators that promote this malignant feature may help yield novel therapeutic insights. Her...
-
Article
Erratum to “Numerical study on the shock vector control performance in a de Laval nozzle with single or dual injection ports”
-
Article
Open AccessCorrection to: ONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY
-
Article
Open AccessONECUT2 facilitates hepatocellular carcinoma metastasis by transcriptionally upregulating FGF2 and ACLY
Metastasis is the predominant reason for high mortality of hepatocellular carcinoma (HCC) patients. It is critical to explore the molecular mechanism underlying HCC metastasis. Here, we reported that transcrip...
-
Article
Open AccessIGF1-mediated HOXA13 overexpression promotes colorectal cancer metastasis through upregulating ACLY and IGF1R
Metastasis is the major reason for the high mortality of colorectal cancer (CRC) patients and its molecular mechanism remains unclear. Here, we report a novel role of Homeobox A13 (HOXA13), a member of the Hom...
-
Article
Open AccessFOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter
Forkhead box C1 (FOXC1), as a member of the FOX family, is important for promote HCC invasion and metastasis. FOX family protein lays a pivotal role in metabolism. ROS is involved in tumor progression and is a...
-
Article
Open AccessIdentification and validation of an individualized autophagy-clinical prognostic index in gastric cancer patients
The purpose of this study is to perform bioinformatics analysis of autophagy-related genes in gastric cancer, and to construct a multi-gene joint signature for predicting the prognosis of gastric cancer.
-
Article
Open AccessHigh-resolution 3D visualization of ductular proliferation of bile duct ligation-induced liver fibrosis in rats using x-ray phase contrast computed tomography
X-ray phase-contrast computed tomography (PCCT) can provide excellent image contrast for soft tissues with small density differences, and it is particularly appropriate for three-dimensional (3D) visualization...
